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	Ppi finder: a mining tool for human protein-protein interactions
	He, Min1,2; Wang, Yi1; Li, Wei1
刊名	Plos one
	2009-02-23
卷号	4期号:2页码:6
ISSN号	1932-6203
DOI	10.1371/journal.pone.0004554
通讯作者	He, min()
英文摘要	Background: the exponential increase of published biomedical literature prompts the use of text mining tools to manage the information overload automatically. one of the most common applications is to mine protein-protein interactions (ppis) from pubmed abstracts. currently, most tools in mining ppis from literature are using co-occurrence-based approaches or rule-based approaches. hybrid methods (frame-based approaches) by combining these two methods may have better performance in predicting ppis. however, the predicted ppis from these methods are rarely evaluated by known ppi databases and co-occurred terms in gene ontology (go) database. methodology/principal findings: we here developed a web-based tool, ppi finder, to mine human ppis from pubmed abstracts based on their co-occurrences and interaction words, followed by evidences in human ppi databases and shared terms in go database. only 28% of the co-occurred pairs in pubmed abstracts appeared in any of the commonly used human ppi databases (hprd, biogrid and bind). on the other hand, of the known ppis in hprd, 69% showed co-occurrences in the literature, and 65% shared go terms. conclusions: ppi finder provides a useful tool for biologists to uncover potential novel ppis. it is freely accessible at http://liweilab.genetics.ac.cn/tm/.
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000265487200010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2394973
专题	中国科学院大学
通讯作者	He, Min
作者单位	1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	He, Min,Wang, Yi,Li, Wei. Ppi finder: a mining tool for human protein-protein interactions[J]. Plos one,2009,4(2):6.
APA	He, Min,Wang, Yi,&Li, Wei.(2009).Ppi finder: a mining tool for human protein-protein interactions.Plos one,4(2),6.
MLA	He, Min,et al."Ppi finder: a mining tool for human protein-protein interactions".Plos one 4.2(2009):6.

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