| An association study of the slc26a4 gene in children with mental retardation | |
| Li, Jun1; Zhang, Fuchang2; Gao, Jianjun1,3; Cai, Zhen3; Zhao, Qian1; Xing, Yi1; Xu, Jie3; Liu, Yun3; Shao, Liyan1; Che, Ronglin1 | |
| 刊名 | Neuroscience letters
 |
| 2009-07-03 | |
| 卷号 | 457期号:3页码:155-158 |
| 关键词 | Slc26a4 Iodine deficiency Mental retardation Iodide flux |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2009.03.099 |
| 通讯作者 | He, lin(helinhelin@gmail.com) |
| 英文摘要 | It is generally considered that iodine deficiency is the single most common cause of preventable mental retardation (mr) and brain damage. the slc26a4 gene is expressed at the apical surface of thyrocytes and its product forms an efficient iodide-trapping mechanism. to investigate whether variability in the slc26a4 gene influences the risk of iodine-deficiency based mr, we undertook an association study between slc26a4 and mr. participants were recruited from a relatively isolated and traditionally iodine-deficient region with a high prevalence of mr. the snps we selected from the dbsnp and hapmap were identified using arms-pcr and sequencing methods. singular-locus and haplotype association analysis indicated no association between the slc26a4 gene and mr (p > 0.05). the negative results suggest that the slc26a4 gene has no measurable impact on iodine-deficiency based mr. in view of the characteristics of our samples, our study may provide a good reference for research into the transport features of pendrin in the thyrocyte apical surface. (c) 2009 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | PENDRED-SYNDROME GENE ; APICAL IODIDE EFFLUX ; THYROID-HORMONES ; PDS ; TRANSPORTERS ; DEFECTS ; CHANNEL ; GOITER ; FAMILY ; GLAND |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000266432500011 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2394641 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, Lin |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Minist Educ, BioX Ctr, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China 2.Northwest Univ, Inst Populat & Hlth, Xian 710069, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 4.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jun,Zhang, Fuchang,Gao, Jianjun,et al. An association study of the slc26a4 gene in children with mental retardation[J]. Neuroscience letters,2009,457(3):155-158. |
| APA | Li, Jun.,Zhang, Fuchang.,Gao, Jianjun.,Cai, Zhen.,Zhao, Qian.,...&He, Lin.(2009).An association study of the slc26a4 gene in children with mental retardation.Neuroscience letters,457(3),155-158. |
| MLA | Li, Jun,et al."An association study of the slc26a4 gene in children with mental retardation".Neuroscience letters 457.3(2009):155-158. |
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