| Variants in kcnq1 are associated with susceptibility to type 2 diabetes in the population of mainland china | |
| Liu, Y.1,2; Zhou, D. Z.1,2; Zhang, D.1,2; Chen, Z.1,2; Zhao, T.1,2; Zhang, Z.1,2; Ning, M.1,2; Hu, X.3; Yang, Y. F.1,2; Zhang, Z. F.4 | |
| 刊名 | Diabetologia
 |
| 2009-07-01 | |
| 卷号 | 52期号:7页码:1315-1321 |
| 关键词 | Association Kcnq1 Mainland chinese population Type 2 diabetes |
| ISSN号 | 0012-186X |
| DOI | 10.1007/s00125-009-1375-y |
| 通讯作者 | He, l.(helin@bio-x.cn) |
| 英文摘要 | Two recent genome-wide association studies have identified several novel type 2 diabetes susceptibility variants in intron 15 of the kcnq1 gene. we aimed to evaluate the effects of the variants in kcnq1 on type 2 diabetes and metabolic traits in the population of mainland china. three candidate single nucleotide polymorphisms were genotyped in 1,912 individuals with type 2 diabetes and 2,041 normal controls using the ligase detection reaction method. we confirmed the association of kcnq1 with type 2 diabetes in the population of mainland china. allele frequency ors of the three single nucleotide polymorphisms (snps) were: rs2237892 (or 1.19, 95% ci 1.08-1.31, p = 3.0 x 10(-4)); rs2237895 (or 1.20, 95% ci 1.09-1.32, p = 1.9 x 10(-4)); and rs2237897 (or 1.24, 95% ci 1.13-1.36, p = 3.9 x 10(-5)). we also found a significant difference in the distribution of the global haplotypes between the type 2 diabetes group and the normal control group (p = 2.6 x 10(-5)). in addition, in the control group snp rs2237892 was marginally associated with increasing fasting plasma glucose and snps rs2237892 and rs2237897 were associated with hba(1c). furthermore, for all three variants, homozygous carriers of the diabetes-associated allele had significantly decreased bmi and waist circumferences. our investigation confirmed the effects of kcnq1 variants on type 2 diabetes risk in the chinese population. |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; POSITIVE ASSOCIATION ; TARGETED DISRUPTION ; HAN POPULATION ; RISK LOCI ; CDKAL1 ; GENES ; IGF2BP2 ; SLC30A8 ; POLYMORPHISM |
| WOS研究方向 | Endocrinology & Metabolism |
| WOS类目 | Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000266496000013 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2394462 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, L. |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China 3.Ruijin Hosp, Luwan Branch, Shanghai, Peoples R China 4.Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA 5.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Y.,Zhou, D. Z.,Zhang, D.,et al. Variants in kcnq1 are associated with susceptibility to type 2 diabetes in the population of mainland china[J]. Diabetologia,2009,52(7):1315-1321. |
| APA | Liu, Y..,Zhou, D. Z..,Zhang, D..,Chen, Z..,Zhao, T..,...&Xu, H..(2009).Variants in kcnq1 are associated with susceptibility to type 2 diabetes in the population of mainland china.Diabetologia,52(7),1315-1321. |
| MLA | Liu, Y.,et al."Variants in kcnq1 are associated with susceptibility to type 2 diabetes in the population of mainland china".Diabetologia 52.7(2009):1315-1321. |
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