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	Contrasting effects of hc-pro and 2b viral suppressors from sugarcane mosaic virus and tomato aspermy cucumovirus on the accumulation of sirnas
	Zhang, Xiaoming1,2; Du, Peng1,2; Lu, Lu1,2; Xiao, Qi1,2; Wang, Wenjuan3; Cao, Xuesong1,2,4; Ren, Bo1,2; Wei, Chunhong1,2; Li, Yi1,2
刊名	Virology
	2008-05-10
卷号	374期号:2页码:351-360
关键词	Rna silencing suppressor Sugarcane mosaic virus Hc-pro 2b 3' secondary sirna 5' secondary sirna Rdr6
ISSN号	0042-6822
DOI	10.1016/j.virol.2007.12.045
通讯作者	Li, yi(liyi@pku.edu.cn)
英文摘要	Rna silencing and suppression of silencing are host and virus interactions for defense and counter-defense. here, we explored the function effect of hc-pro encoded by sugarcane mosaic virus (scmv) on the suppression of rna silencing. sirna northern blotting assay indicated that the replication of scmv was regulated by host rna silencing machinery. co-expression assay demonstrated that the hc-pro encoded by scmv suppressed the rna silencing induced by sense rna and dsrna. transitive rna silencing assay showed that hc-pro down-regulated the accumulation of 3' secondary sirna, but not 5' secondary and primary sirna. meanwhile, the 2b gene of tomato aspermy cucumovirus (tav) evidently down-regulated the accumulation of 5' secondary sirna. importantly, we found that hc-pro and tav2b down-regulated the accumulation of rdr6 mrna. thus, hc-pro, an rna silencing suppressor encoded by scmv, regulates the accumulation of different sirnas and has more than one target in the rna silencing pathway. (c) 2008 elsevier inc. all rights reserved.
WOS关键词	DEPENDENT RNA-POLYMERASE ; DOUBLE-STRANDED-RNA ; TRANS-ACTING SIRNAS ; SILENCING SIGNAL ; INTERFERING RNA ; COAT PROTEIN ; CAENORHABDITIS-ELEGANS ; ANTIVIRAL IMMUNITY ; ENCODED SUPPRESSOR ; INITIATION STEP
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000255735900014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2389126
专题	中国科学院大学
通讯作者	Li, Yi
作者单位	1.Peking Univ, Peking Yale Joint Ctr Plant Mol Genet & Agrobiote, Natl Lab Prot Engn & Plant Genet Engn, Coll Life Sci, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, Natl Ctr Plant Gene Res Beijing, Beijing 100871, Peoples R China 3.Capital Normal Univ, Coll Life Sci, Beijing 100037, Peoples R China 4.Liaocheng Univ, Coll Life Sci, Liaocheng 252059, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaoming,Du, Peng,Lu, Lu,et al. Contrasting effects of hc-pro and 2b viral suppressors from sugarcane mosaic virus and tomato aspermy cucumovirus on the accumulation of sirnas[J]. Virology,2008,374(2):351-360.
APA	Zhang, Xiaoming.,Du, Peng.,Lu, Lu.,Xiao, Qi.,Wang, Wenjuan.,...&Li, Yi.(2008).Contrasting effects of hc-pro and 2b viral suppressors from sugarcane mosaic virus and tomato aspermy cucumovirus on the accumulation of sirnas.Virology,374(2),351-360.
MLA	Zhang, Xiaoming,et al."Contrasting effects of hc-pro and 2b viral suppressors from sugarcane mosaic virus and tomato aspermy cucumovirus on the accumulation of sirnas".Virology 374.2(2008):351-360.

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