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	Polyhydroxylated fullerene derivative c-60(oh)(24) prevents mitochondrial dysfunction and oxidative damage in an mpp+-induced cellular model of parkinson's disease
	Cai, Xiaoqing2,3,4; Jia, Haiqun3,4; Liu, Zhongbo3,4; Hou, Bei3; Luo, Cheng3; Feng, Zhihui3,4; Li, Wenxin2; Liu, Jiankang1
刊名	Journal of neuroscience research
	2008-12-01
卷号	86期号:16页码:3622-3634
关键词	1-methyl-4-phenylpyridinium (mpp+) Dna damage Protein oxidation Free radical Phase 2 enzymes
ISSN号	0360-4012
DOI	10.1002/jnr.21805
通讯作者	Liu, jiankang(j.liu@mail.xjtu.edu.cn)
英文摘要	To find effective agents for parkinson's disease (pd) prevention and therapy, we examined the protective effects of the polyhydroxylated fullerene derivative c-60(oh)(24) in a 1-methyl-4-phenylpyridinium (mpp+)-induced acute cellular pd model in human neuroblastoma cells and the free radical scavenging effects in this model with an electron spin resonance (esr) spectrometer. pretreatment with c-60(oh)(24) at concentrations greater than 20 mu m showed significant protective effects on mpp+-induced loss in cell viability, decreases in mitochondrial function (including mitochondrial membrane potential and activities of complex i and ii), and increases in the levels of reactive oxygen species and oxidative damage to dna and proteins. in addition, c-60(oh)(24) acts as a phase 2 enzyme inducer to protect cells from mpp+-induced decreases in expression of nuclear factor-e2-related factor 2, expression and activity of gamma-glutamyl cysteine ligase and level of glutathione. the esr study showed that c-60(oh)(24) is a powerful radical scavenger for superoxide, hydroxyl, and lipid radicals. these data suggest that c-60(oh)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity. (c) 2008 wiley-liss, inc.
WOS关键词	ALPHA-KETOGLUTARATE DEHYDROGENASE ; IN-VIVO ; NEUROPROTECTIVE AGENTS ; LIPOIC ACID ; COMPLEX-I ; C-60 ; TOXICITY ; MECHANISM ; NEURONS ; CELLS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000261651900014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2389008
专题	中国科学院大学
通讯作者	Liu, Jiankang
作者单位	1.Xian Jiaotong Univ, Sch Life Sci & Technol, Inst Mitochondrial Biol & Med, Xian 710049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Sci, Lab Nanobiol & Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biolsci, Inst Nutr Sci, Shanghai, Peoples R China 4.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Cai, Xiaoqing,Jia, Haiqun,Liu, Zhongbo,et al. Polyhydroxylated fullerene derivative c-60(oh)(24) prevents mitochondrial dysfunction and oxidative damage in an mpp+-induced cellular model of parkinson's disease[J]. Journal of neuroscience research,2008,86(16):3622-3634.
APA	Cai, Xiaoqing.,Jia, Haiqun.,Liu, Zhongbo.,Hou, Bei.,Luo, Cheng.,...&Liu, Jiankang.(2008).Polyhydroxylated fullerene derivative c-60(oh)(24) prevents mitochondrial dysfunction and oxidative damage in an mpp+-induced cellular model of parkinson's disease.Journal of neuroscience research,86(16),3622-3634.
MLA	Cai, Xiaoqing,et al."Polyhydroxylated fullerene derivative c-60(oh)(24) prevents mitochondrial dysfunction and oxidative damage in an mpp+-induced cellular model of parkinson's disease".Journal of neuroscience research 86.16(2008):3622-3634.

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