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	Binding of v-iv to human transferrin: potential relevance to anticancer activity of vanadocene dichloride
	Du, Hongyan1,2; Xiang, Junfeng1; Zhang, Yazhou1,2; Tang, Yalin1; Xu, Guangzhi1
刊名	Journal of inorganic biochemistry
	2008
卷号	102期号:1页码:146-149
关键词	Transferrin Vanadocene dichloride Targeting delivery Antitumor activity
ISSN号	0162-0134
DOI	10.1016/j.jinorgbio.2007.07.030
通讯作者	Tang, yalin(tangyl@iccas.ac.cn)
英文摘要	The action mechanism of vanadocene dichloride, cp2vcl2 (cp = eta(5)-c5h5), has been investigated by interaction with human serum transferrin for its promising antitumor activities. our results have shown that cp2vci2, binds to transferrin and form a new complex, and the calculated apparent association constant is 1.37 x 10(5) m-1 from the fluorescence quenching. simultaneously, the variation of the secondary structure of transferrin occurs, most probably due to the coordination of the amino residues of protein with v-iv. it was evidenced that cp is released free in solution after v-iv binding to transferrin by h-1 nmr measurements. these results have shown that cp2vcl2, forms a complex with transferrin, which may provide a possible pathway in the transport and targeted delivery of the antitumor agent. (c) 2007 elsevier inc. all rights reserved.
WOS关键词	HUMAN SERUM TRANSFERRIN ; RECEPTOR-MEDIATED ENDOCYTOSIS ; ANTITUMOR AGENTS ; MECHANISTIC IMPLICATIONS ; METALLOCENE DICHLORIDES ; DRUG-DELIVERY ; N-LOBE ; CELLS ; V(ETA-5-C5H5)2CL2 ; COMMUNICATION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000252523200015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2387343
专题	中国科学院大学
通讯作者	Tang, Yalin
作者单位	1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,et al. Binding of v-iv to human transferrin: potential relevance to anticancer activity of vanadocene dichloride[J]. Journal of inorganic biochemistry,2008,102(1):146-149.
APA	Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,Tang, Yalin,&Xu, Guangzhi.(2008).Binding of v-iv to human transferrin: potential relevance to anticancer activity of vanadocene dichloride.Journal of inorganic biochemistry,102(1),146-149.
MLA	Du, Hongyan,et al."Binding of v-iv to human transferrin: potential relevance to anticancer activity of vanadocene dichloride".Journal of inorganic biochemistry 102.1(2008):146-149.

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