| Lack of association between hla-a, -b and-drb1 alleles and the development of sars: a cohort of 95 sars-recovered individuals in a population of guangdong, southern china | |
| Xiong, P.2; Zeng, X.3; Song, M. S.1,6; Jia, S. W.4; Zhong, M. H.2; Xiao, L. L.5; Lan, W.; Cai, C.3; Wu, X. W.2; Gong, F. L.2 | |
| 刊名 | International journal of immunogenetics
 |
| 2008-02-01 | |
| 卷号 | 35期号:1页码:69-74 |
| ISSN号 | 1744-3121 |
| DOI | 10.1111/j.1744-313x.2007.00741.x |
| 通讯作者 | Wang, w.(wei6014@yahoo.com) |
| 英文摘要 | Severe acute respiratory syndrome (sars), caused by infection with a novel coronavirus (sars-cov), was the first major novel infectious disease at the beginning of the 21st century, with china especially affected. sars was characterized by high infectivity, morbidity and mortality, and the confined pattern of the disease spreading among the countries of south-east and east asia suggested the existence of susceptible factor(s) in these populations. studies in the populations of hong kong and taiwan showed an association of human leucocyte antigen (hla) polymorphisms with the development and/or severity of sars, respectively. the aim of the present study was to define the genotypic patterns of hla-a, -b and -drb1 loci in sars patients and a co-resident population of guangdong province, southern china, where the first sars case was reported. the samples comprised 95 cases of recovered sars patients and 403 unrelated healthy controls. hla -a, -b and -drb1 alleles were genotyped using polymerase chain reaction with sequence-specific primers. the severity of the disease was assessed according to the history of lung infiltration, usage of assisted ventilation and occurrence of lymphocytopenia. although the allelic frequencies of a23, a34, b60, drb1*12 in the sars group were slightly higher, and a33, -b58 and -b61 were lower than in the controls, no statistical significance was found when the pc value was considered. similarly, no association of hla alleles with the severity of the disease was detected. thus, variations in the major histocompatibility complex are unlikely to have contributed significantly to either the susceptibility or the severity of sars in the population of guangdong. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; ANTIGEN CLASS-I ; VIETNAMESE POPULATION ; POLYMORPHISMS ; CORONAVIRUS ; GENES ; SUSCEPTIBILITY ; FREQUENCIES ; RESISTANCE ; INFECTION |
| WOS研究方向 | Genetics & Heredity ; Immunology |
| WOS类目 | Genetics & Heredity ; Immunology |
| 语种 | 英语 |
| 出版者 | BLACKWELL PUBLISHING |
| WOS记录号 | WOS:000252120400012 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2385448 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, W. |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Coll Life Sci, Dept Biol, Beijing 100049, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430074, Peoples R China 3.Guangdong Prov TCM Hosp, Guangzhou, Peoples R China 4.Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China 5.Sun Yat Sen Univ, Tissue Typing Ctr, Guangzhou, Peoples R China 6.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, P.,Zeng, X.,Song, M. S.,et al. Lack of association between hla-a, -b and-drb1 alleles and the development of sars: a cohort of 95 sars-recovered individuals in a population of guangdong, southern china[J]. International journal of immunogenetics,2008,35(1):69-74. |
| APA | Xiong, P..,Zeng, X..,Song, M. S..,Jia, S. W..,Zhong, M. H..,...&Wang, W..(2008).Lack of association between hla-a, -b and-drb1 alleles and the development of sars: a cohort of 95 sars-recovered individuals in a population of guangdong, southern china.International journal of immunogenetics,35(1),69-74. |
| MLA | Xiong, P.,et al."Lack of association between hla-a, -b and-drb1 alleles and the development of sars: a cohort of 95 sars-recovered individuals in a population of guangdong, southern china".International journal of immunogenetics 35.1(2008):69-74. |
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