| Effects of bmk as on nav1.2 expressed in xenopus laevis oocytes | |
| Tan, Miao2; Zhu, Mang-Mang2; Liu, Ying2; Cheng, Hui-Wen1; Ji, Yong-Hua1 | |
| 刊名 | Cell biology and toxicology
 |
| 2008-04-01 | |
| 卷号 | 24期号:2页码:143-149 |
| 关键词 | Expressed rnav1.2 Scorpion toxin Bmk as |
| ISSN号 | 0742-2091 |
| DOI | 10.1007/s10565-007-9023-0 |
| 通讯作者 | Ji, yong-hua(yhji@server.shcnc.ac.cn) |
| 英文摘要 | In the present study, the pharmacological effects of bmk as, a beta-like scorpion toxin on rnav1.2 alpha-subunit expressed in xenopus laevis oocytes were investigated using a two-electrode voltage-clamp recording. it was found that the voltage dependence of rnav1.2 inactivation was significantly shifted towards positive membrane potential by 500 nm bmk as, whereas the activation curves of rnav1.2 were unruffled at the same dosage. the inactivation curves of both slow and fast inactivation currents were positively moved about 12.8 and 9.7 mv, respectively. in addition, the persistent currents of rnav1.2 were invariable. the effects of bmk as on the rnav1.2 inactivation were opposite to the previous results found in the peripheral sensory neurons. the results suggested that nav1.2 might be the target of bmk as in the central nervous system, and bmk as might have an excitatory effect on the central neuron through enhancing nav1.2. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; GATED SODIUM-CHANNELS ; RYANODINE RECEPTOR ; SKELETAL-MUSCLE ; SCORPION TOXIN ; MESSENGER-RNA ; NA+ CURRENTS ; RAT ; POLYPEPTIDE ; MECHANISM |
| WOS研究方向 | Cell Biology ; Toxicology |
| WOS类目 | Cell Biology ; Toxicology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000253524700002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2385411 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Physiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Miao,Zhu, Mang-Mang,Liu, Ying,et al. Effects of bmk as on nav1.2 expressed in xenopus laevis oocytes[J]. Cell biology and toxicology,2008,24(2):143-149. |
| APA | Tan, Miao,Zhu, Mang-Mang,Liu, Ying,Cheng, Hui-Wen,&Ji, Yong-Hua.(2008).Effects of bmk as on nav1.2 expressed in xenopus laevis oocytes.Cell biology and toxicology,24(2),143-149. |
| MLA | Tan, Miao,et al."Effects of bmk as on nav1.2 expressed in xenopus laevis oocytes".Cell biology and toxicology 24.2(2008):143-149. |
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