QQ客服 官方微博 反馈留言

	Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase
	Huang, Hui; Wu, Dan; Tian, Wei-Xi; Ma, Xiao-Feng; Wu, Xiao-Dong
刊名	Journal of enzyme inhibition and medicinal chemistry
	2008
卷号	23期号:3页码:362-368
关键词	Galangal Beta-ketoacyl-acp reductase (fabg) Antibacterial Inhibition Kinetic
ISSN号	1475-6366
DOI	10.1080/14756360701622099
通讯作者	Wu, xiao-dong(wuxd@gucas.ac.cn)
英文摘要	Inhibitory effects on bacterial growth showed that 40% ethanol extract of galangal (rhizome of alpinia officinarum hance) can inhibit staphylococcus aureus, alpha-hemolytic streptococcus, beta-hemolytic streptococcus and streptococcus pneumoniae. beta-ketoacyl-acp reductase (fabg, ec.1.1.1.100) is a key enzyme in type ii fatty acid synthase system in bacteria and catalyzes beta-ketoacyl-acp reduction. the galangal extracts inhibited fabg with an ic(50) value of only 4.47 +/- 0.10 mu g/ml and is more potent than other previously published inhibitors. kinetics studies showed that the inhibition consisted of both reversible and irreversible inhibition. the extracts of galangal inhibit fabg in a competitive pattern against nadph. so far, no inhibitor has been reported to exhibit irreversible inhibition of fabg, whereas the galangal ethanol extract can inhibit fabg irreversibly. the irreversible inhibition presented two phases. it is probable that the galangal extract inhibit fabg, thereby displaying antibacterial ability.
WOS关键词	FATTY-ACID SYNTHESIS ; ESCHERICHIA-COLI ; SYNTHASE ; FABG ; BIOSYNTHESIS ; GALANGAL ; TARGETS
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Medicinal
语种	英语
出版者	INFORMA HEALTHCARE
WOS记录号	WOS:000256753000011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2385352
专题	中国科学院大学
通讯作者	Wu, Xiao-Dong
作者单位	Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Huang, Hui,Wu, Dan,Tian, Wei-Xi,et al. Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase[J]. Journal of enzyme inhibition and medicinal chemistry,2008,23(3):362-368.
APA	Huang, Hui,Wu, Dan,Tian, Wei-Xi,Ma, Xiao-Feng,&Wu, Xiao-Dong.(2008).Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase.Journal of enzyme inhibition and medicinal chemistry,23(3),362-368.
MLA	Huang, Hui,et al."Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase".Journal of enzyme inhibition and medicinal chemistry 23.3(2008):362-368.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。