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	Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions
	Jiang, Zhiqiang1,2; Hao, Jianyuan1,2; You, YuJing; Liu, Yan3; Wang, Zhenhong3; Deng, Xianmo1,2
刊名	Journal of biomedical materials research part a
	2008-10-01
卷号	87a期号:1页码:45-51
关键词	Biomaterials Hydrogels Sol-gel Block copolymer Biodegradable
ISSN号	1549-3296
DOI	10.1002/jbm.a.31699
通讯作者	Hao, jianyuan(j.hao@cioc.ac.cn)
英文摘要	The aqueous solutions of triblock copolymers of poly(ethylene glycol)-poly(epsilon-caprolactoiie-co-glycolide)-poly(eihylene glycol) [peg-p(cl-ga)-peg] undergoing sol-gel transition as the temperature increases from 20 to 60 degrees c were successfully prepared. the thermogelling block copolymers were synthesized by subtle control of the hydrophilic/hydrophobic balance and the chain microstructures. the amphiphilic block copolymer formed micelles in aqueous solution, and the micelle aggregated as the temperature increased. the sol-gel transition of the copolymer aqueous solutions was studied focusing on the structure-property relationship. ga was incorporated into the polymer chain to prevent crystallization of pcl component and increase the polymer degradation. it is expected to be a promising long-term delivery system for ph-sensitive drugs, proteins, and genes. (c) 2007 wiley periodicals, inc.
WOS关键词	STRUCTURE-PROPERTY RELATIONSHIPS ; RING-OPENING POLYMERIZATION ; MIXED TRIBLOCK COPOLYMERS ; PLGA-PEG-PLGA ; BLOCK-COPOLYMERS ; CAPILLARY-ELECTROPHORESIS ; EPSILON-CAPROLACTONE ; DNA SEPARATION ; DELIVERY ; ASSOCIATION
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	WILEY-LISS
WOS记录号	WOS:000259129500007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2385350
专题	中国科学院大学
通讯作者	Hao, Jianyuan
作者单位	1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Univ, Dept Chem, Beijing 100039, Peoples R China 3.Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat & Engn, Chengdu 610065, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Zhiqiang,Hao, Jianyuan,You, YuJing,et al. Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions[J]. Journal of biomedical materials research part a,2008,87a(1):45-51.
APA	Jiang, Zhiqiang,Hao, Jianyuan,You, YuJing,Liu, Yan,Wang, Zhenhong,&Deng, Xianmo.(2008).Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions.Journal of biomedical materials research part a,87a(1),45-51.
MLA	Jiang, Zhiqiang,et al."Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions".Journal of biomedical materials research part a 87a.1(2008):45-51.

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