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	Rapid label-free detection of metal-induced alzheimer's amyloid beta peptide aggregation by electrochemical method
	Geng, Jie; Yu, Haijia; Ren, Jinsong; Qu, Xiaogang
刊名	Electrochemistry communications
	2008-11-01
卷号	10期号:11页码:1797-1800
关键词	A beta aggregation Metal Electrochemistry Tyrosine
ISSN号	1388-2481
DOI	10.1016/j.elecom.2008.09.020
通讯作者	Qu, xiaogang(xqu@ciac.jl.cn)
英文摘要	Amyloid beta peptide plays a critical role in the pathogenesis of alzheimer's disease (ad). metal ions are highly enriched in cerebral amyloid deposits in ad and are proposed to be able to mediate a beta conformation. therefore, a rapid, low-cost, and sensitive detection of metal-induced a beta aggregation and their relation to ad is clearly needed for the clinical diagnosis and treatment. in this report, we study metal-induced a beta aggregation by a rapid, label-free electrochemical method and monitor both the aggregation kinetics and the morphology in the absence or presence of zn (ii) and cu (ii). different electrochemical behaviors of a beta in the absence or presence of metal ions have been observed both in the aggregation kinetics and final aggregates. our results provide new insights into the application of the rapid, low-cost and sensitive electrochemical device for clinical diagnosis of metal effects on ad or other neurodegenerative diseases which are related to protein misfolding. (c) 2008 elsevier b.v. all rights reserved.
WOS关键词	A-BETA ; FIBRIL FORMATION ; GOLD ELECTRODES ; ALPHA-SYNUCLEIN ; CYTOCHROME-C ; IN-VITRO ; DISEASE ; PROTEIN ; COPPER ; BINDING
WOS研究方向	Electrochemistry
WOS类目	Electrochemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000260992900036
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2385056
专题	中国科学院大学
通讯作者	Qu, Xiaogang
作者单位	Chinese Acad Sci, Grad Sch, Changchun Inst Appl Chem, Div Biol Inorgan Chem,State Key Lab Rare Earth Re, Changchun 130022, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Geng, Jie,Yu, Haijia,Ren, Jinsong,et al. Rapid label-free detection of metal-induced alzheimer's amyloid beta peptide aggregation by electrochemical method[J]. Electrochemistry communications,2008,10(11):1797-1800.
APA	Geng, Jie,Yu, Haijia,Ren, Jinsong,&Qu, Xiaogang.(2008).Rapid label-free detection of metal-induced alzheimer's amyloid beta peptide aggregation by electrochemical method.Electrochemistry communications,10(11),1797-1800.
MLA	Geng, Jie,et al."Rapid label-free detection of metal-induced alzheimer's amyloid beta peptide aggregation by electrochemical method".Electrochemistry communications 10.11(2008):1797-1800.

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