Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands

	Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands
	Qiu, Min 1,2; Wang, Dao-Yong 1,2; Hu, Xiang-Ping 1; Huang, Jia-Di 1,2; Yu, Sai-Bo 1,2; Deng, Jun 1,2; Duan, Zheng-Chao 1,2; Zheng, Zhuo 1
刊名	tetrahedron-asymmetry
	2009-02-12
卷号	20 期号:2 页码:210-213
通讯作者	郑卓
产权排序	1;1
英文摘要	methyl 3-hydroxy-2-methylpropionate, known as the roche ester, was prepared with high enantioselectivity (up to 96.7% ee) via the rh-catalyzed asymmetric hydrogenation of methyl 2-hydroxymethylacrylate with a chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (thnaphos 5a) even at a low catalyst loading (0.1 mol %). an investigation on the substrate scope revealed that the ester group present in the substrate has a significant effect on the enantioselectivity, and the substrate with the bulkier ester group tended to give lower enantioselectivity. (c) 2009 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, inorganic & nuclear ; chemistry, organic ; chemistry, physical
研究领域[WOS]	chemistry
关键词[WOS]	beta-hydroxyisobutyric acid ; absolute-configuration ; building-blocks ; natural-product ; scale synthesis ; (+)-discodermolide ; oxidation ; alpha
收录类别	SCI ; IC
原文出处	false
语种	英语
WOS记录号	WOS:000264648900009
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/102359]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Min,Wang, Dao-Yong,Hu, Xiang-Ping,et al. Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands[J]. tetrahedron-asymmetry,2009,20(2):210-213.
APA	Qiu, Min.,Wang, Dao-Yong.,Hu, Xiang-Ping.,Huang, Jia-Di.,Yu, Sai-Bo.,...&Zheng, Zhuo.(2009).Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands.tetrahedron-asymmetry,20(2),210-213.
MLA	Qiu, Min,et al."Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands".tetrahedron-asymmetry 20.2(2009):210-213.