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	Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin
	Zhou Qiu-Ju1,2; Bi Ya-Jing1; Xiang Jun-Feng1; Tang Ya-Lin1; Yang Qian-Fan1,2; Xu Guang-Zhi1
刊名	Chinese journal of chemistry
	2008-08-01
卷号	26期号:8页码:1385-1389
关键词	Targeting drug delivery system Mitoxantrone Human serum albumin Folate Cytotoxicity assay
ISSN号	1001-604X
通讯作者	Tang ya-lin(tangyl@iccas.ac.cn)
英文摘要	A potential targeting drug delivery system consisting of folate (fa), the targeting molecule, human serum albumin (hsa), the carrier, and mitoxantrone (mto), the medicine, has been designed. data obtained by uv absorption, fluorescence, and nmr techniques indicated the formation of ternary complexes and possible application to building a targeting drug delivery system by using fa, mto and hsa. furthermore, cytotoxicity assay indicated that the toxicity of the fa-hsa-mto against pc-3 cell line was 79.95%, which was much higher than thin of free mto tested in totally the same conditions. about 30% increase of the toxicity should be owed to the targeting effect of fa. thus, the feasibility and validity of a novel targeting drug delivery system, fa-hsa-mto, was confirmed.
WOS关键词	MULTIPLE-SCLEROSIS ; IN-VIVO ; CHEMISTRY ; DYE
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000258940100006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2384171
专题	中国科学院大学
通讯作者	Tang Ya-Lin
作者单位	1.Chinese Acad Sci, BNLMS, Ctr Mol Sci,Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou Qiu-Ju,Bi Ya-Jing,Xiang Jun-Feng,et al. Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin[J]. Chinese journal of chemistry,2008,26(8):1385-1389.
APA	Zhou Qiu-Ju,Bi Ya-Jing,Xiang Jun-Feng,Tang Ya-Lin,Yang Qian-Fan,&Xu Guang-Zhi.(2008).Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin.Chinese journal of chemistry,26(8),1385-1389.
MLA	Zhou Qiu-Ju,et al."Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin".Chinese journal of chemistry 26.8(2008):1385-1389.

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