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	Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine
	Shi, Yong; Zhang, Xinyang; Wan, Jia; Wang, Yong; Yin, Wei; Cao, Zhiwei; Guo, Yajun
刊名	Neural computing & applications
	2007-05-01
卷号	16期号:4-5页码:481-490
关键词	Bioinformatics Protein Protein data bank Antibody-antigen complexes Support vector machine Cross-validation
ISSN号	0941-0643
DOI	10.1007/s00521-006-0076-4
通讯作者	Shi, yong(yshi@gucas.ac.cn)
英文摘要	In this paper, a machine learning approach, known as support vector machine (svm) is employed to predict the distance between antibody's interface residue and antigen in antigen-antibody complex. the heavy chains, light chains and the corresponding antigens of 37 antibodies are extracted from the antibody-antigen complexes in protein data bank. according to different distance ranges, sequence patch sizes and antigen classes, a number of, computational experiments are conducted to describe the distance between antibody's interface residue and antigen with antibody sequence information. the high prediction accuracy of both self-consistent and cross-validation tests indicates that the sequential discovered information from antibody structure characterizes much in predicting the distance between antibody's interface residue and antigen. furthermore, the antigen class is predicted from residue composition information that belongs to different distance range by svm, which shows some potential significance.
WOS关键词	PROTEIN INTERACTION SITES ; SOLVENT ACCESSIBILITY ; PATTERN-RECOGNITION ; EXPRESSION DATA ; SEQUENCE ; CLASSIFICATION ; INFORMATION ; NETWORKS ; COMPLEX
WOS研究方向	Computer Science
WOS类目	Computer Science, Artificial Intelligence
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000247428700015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2383551
专题	中国科学院大学
通讯作者	Shi, Yong
作者单位	1.Chinese Acad Sci, Grad Univ, Res Ctr Data Technol & Knowledge Econ, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 3.Osaka Sangyo Univ, Dept Elect Engn & Elect, Osaka 5748530, Japan 4.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 5.Shanghai Int Canc Inst China, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Shi, Yong,Zhang, Xinyang,Wan, Jia,et al. Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine[J]. Neural computing & applications,2007,16(4-5):481-490.
APA	Shi, Yong.,Zhang, Xinyang.,Wan, Jia.,Wang, Yong.,Yin, Wei.,...&Guo, Yajun.(2007).Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine.Neural computing & applications,16(4-5),481-490.
MLA	Shi, Yong,et al."Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine".Neural computing & applications 16.4-5(2007):481-490.

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