In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa

	In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa
	Wang, Xiao-na 2; Xu, Li-na 2; Peng, Jin-yong 1,2; Liu, Ke-xin 2; Zhang, Li-hua 1; Zhang, Yu-kui 1
刊名	planta medica
	2009-09-01
卷号	75 期号:11 页码:1215-1220
关键词	Coptis chinensis Franch Evodia rutaecarpa (Juss.) Benth Zuojinwan synergy Ranunculaceae Rutaceae
通讯作者	彭金咏 ; 张丽华
产权排序	2;3
英文摘要	the aim of the present paper was to investigate the synergistic effect and mechanism of anticancer activity of zuojinwan (zjw) comprising coptis chinensis franch (hl) and evodia rutaecarpa (juss.) benth (wzy) at a ratio of 6: 1 (w/w). in vivo anticancer activity testing was carried out by inhibiting the growth of s180 tumor. tumor growth inhibition, spleen index, lymphocyte proliferation, apoptosis, tumor necrosis factor-alpha (tnf-alpha) level, activities of serum tumor markers (tms), increase in life span (ils), histopathology and gene expression were tested. the results indicated that zjw could significantly induce apoptosis of cancer cells. the inhibition ratio, ils and tnf-alpha levels of mice treated with zjw were 50.54%, 64.91% and 1.04 ng/ml, respectively, much higher than hl and wzy when singly used. furthermore, the activities of acid phosphatase and alkaline phosphatase were significantly increased and the activities of creatine kinase, aldolase and lactate dehydrogenase were reduced in serum, and the expressions of bax and wild-type p53 proteins were much higher for the mice treated by zjw compared with hl and wzy single-treatment groups. a clear synergistic effect on the anticancer activity was observed with zjw, and the mechanism of antitumor growth may be due to an effect on gene expression and activities of tumor markers in serum.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	multidrug-resistance ; cancer-cells ; mechanisms ; berberine ; apoptosis ; extract ; growth ; genes ; rats ; p53
收录类别	SCI
原文出处	false
语种	英语
WOS记录号	WOS:000270401600006
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/102205]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China 2.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiao-na,Xu, Li-na,Peng, Jin-yong,et al. In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa[J]. planta medica,2009,75(11):1215-1220.
APA	Wang, Xiao-na,Xu, Li-na,Peng, Jin-yong,Liu, Ke-xin,Zhang, Li-hua,&Zhang, Yu-kui.(2009).In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa.planta medica,75(11),1215-1220.
MLA	Wang, Xiao-na,et al."In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa".planta medica 75.11(2009):1215-1220.