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	Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells
	Chen, Yongzheng1,2; Xu, Jinggang; Xu, Xiaoying1; Xia, Yu1; Lin, Hui1; Xia, Shiwen1; Wang, Lixin1
刊名	Tetrahedron-asymmetry
	2007-10-22
卷号	18期号:21页码:2537-2540
ISSN号	0957-4166
DOI	10.1016/j.tetasy.2007.09.029
通讯作者	Xia, shiwen(swxia2008@hotmail.com)
英文摘要	Forty one microorganisms belonging to different taxonomical groups were used to carry out the enantio selective reduction of methyl benzoylformate to afford the corresponding (r)-methyl mandelate, with moderate to high ee. in contrast, the monooxygenase enzyme in helminthosporium sp. cioc3.3316 catalyzed the hydroxylation of methyl 2-phenylacetate to (s)-methyl mandelate. this combination of oxidation and reduction biotransformations thus provides a method for preparing the enantiomers of chiral alpha-hydroxy acid derivatives. (c) 2007 elsevier ltd. all rights reserved.
WOS关键词	DYNAMIC KINETIC RESOLUTION ; CARBOXYLIC-ACIDS ; ASYMMETRIC REDUCTION ; CARBONYL REDUCTASE ; GREEN CHEMISTRY ; ENZYMES
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000251621600007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2382652
专题	中国科学院大学
通讯作者	Xia, Shiwen
作者单位	1.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yongzheng,Xu, Jinggang,Xu, Xiaoying,et al. Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells[J]. Tetrahedron-asymmetry,2007,18(21):2537-2540.
APA	Chen, Yongzheng.,Xu, Jinggang.,Xu, Xiaoying.,Xia, Yu.,Lin, Hui.,...&Wang, Lixin.(2007).Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells.Tetrahedron-asymmetry,18(21),2537-2540.
MLA	Chen, Yongzheng,et al."Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells".Tetrahedron-asymmetry 18.21(2007):2537-2540.

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