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	Different amino-acid substitutions confer insecticide resistance through acetyleholinesterase 1 insensitivity in culex vishnui and culex tritaeniorhynchus (diptera : culicidae) from china
	Alout, Haoues; Berthomieu, Arnaud; Cui, Feng; Tan, Yi; Berticat, Claire; Qiao, Chuanling; Weill, Mylene
刊名	Journal of medical entomology
	2007-05-01
卷号	44期号:3页码:463-469
关键词	Culex tritaeniorhynchus Culex pipiens Insecticide resistance Acetylcholinesterase insensitivity
ISSN号	0022-2585
通讯作者	Weill, mylene(weill@isem.univ-montp2.fr)
英文摘要	Insecticide resistance owing to insensitive acetylcholinesterase (ache)1 has been reported in several mosquito species, and only two mutations in the ace-1 gene have been implicated in resistance: 119s and 331w substitutions. we analyzed the ache1 resistance status of culex vishnui (theobald) and culex tritaeniorhynchus giles sampled in various regions of china. these two species displayed distinct mutations leading to ache1 insensitivity; the 119s substitution in resistant c. vishnui mosquitoes and the 331w substitution in resistant c. tritaeniorhynchus. a biochemical test was validated to detect the 331w mutation in field samples. the comparison of the recombinant g119s and 331w mutant proteins produced in vitro with the ache1 extracted from resistant mosquitoes indicated that the ache1 insensitivity observed could be specifically attributed to these substitutions. comparison of their biochemical characteristics indicated that the resistance conferred by these mutations depends on the insecticide used, regardless of its class. this resistance seemed to be fixed in the cx. tritaeniorhynchus populations sampled in a 2,000-km transect, suggesting a very high level of insecticide application or a low fitness cost associated with this 331w mutation.
WOS关键词	APHIS-GOSSYPII GLOVER ; LUCILIA-CUPRINA ; DROSOPHILA-MELANOGASTER ; DIAZINON RESISTANCE ; MOSQUITO VECTORS ; PIPIENS DIPTERA ; ACETYLCHOLINESTERASE ; MUTATIONS ; IDENTIFICATION ; ORGANOPHOSPHATE
WOS研究方向	Entomology ; Veterinary Sciences
WOS类目	Entomology ; Veterinary Sciences
语种	英语
出版者	ENTOMOLOGICAL SOCIETY AMERICA
WOS记录号	WOS:000246328500010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2382586
专题	中国科学院大学
通讯作者	Weill, Mylene
作者单位	1.Univ Montpellier 2, Team Genet Adapt, Lab Genet & Environm, Inst Sci Evolut,UMR CNRS 5554,CC 065, F-34095 Montpellier 05, France 2.Chinese Acad Sci, Grad Sch, State Key Lab Integrated Management Pest Insects, Inst Zool, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Alout, Haoues,Berthomieu, Arnaud,Cui, Feng,et al. Different amino-acid substitutions confer insecticide resistance through acetyleholinesterase 1 insensitivity in culex vishnui and culex tritaeniorhynchus (diptera : culicidae) from china[J]. Journal of medical entomology,2007,44(3):463-469.
APA	Alout, Haoues.,Berthomieu, Arnaud.,Cui, Feng.,Tan, Yi.,Berticat, Claire.,...&Weill, Mylene.(2007).Different amino-acid substitutions confer insecticide resistance through acetyleholinesterase 1 insensitivity in culex vishnui and culex tritaeniorhynchus (diptera : culicidae) from china.Journal of medical entomology,44(3),463-469.
MLA	Alout, Haoues,et al."Different amino-acid substitutions confer insecticide resistance through acetyleholinesterase 1 insensitivity in culex vishnui and culex tritaeniorhynchus (diptera : culicidae) from china".Journal of medical entomology 44.3(2007):463-469.

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