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	Photodynamic properties of hypocrellin a, complexes with rare earth trivalent ions: role of the excited state energies of the metal ions
	Zeng, Zhanghua; Zhou, Jiahong; Zhang, Yan; Qiao, Rui; Xia, Shengqin; Chen, Jinrong; Wang, Xuesong; Zhang, Baowen
刊名	Journal of physical chemistry b
	2007-03-15
卷号	111期号:10页码:2688-2696
ISSN号	1520-6106
DOI	10.1021/jp067020t
通讯作者	Wang, xuesong(xswang@mail.ipc.ac.cn)
英文摘要	Fifteen complexes of hypocrellin a (ha) with rare earth trivalent ions (except pm3+) along with the complex of ha with sc3+ were prepared, and their photodynamic activities, including absorption in the phototherapeutic window (600-900 nm); water-solubility; triplet lifetime; generation of reactive oxygen species (ros), such as singlet oxygen (o-1(2)), superoxide anion radical (o-2(-center dot)), and hydroxyl radical (oh center dot); generation of semiquinone anion radical; and affinity to dna, as well as photosensitized damage on calf thymus dna (ct dna), were compared in detail using the uv-visible spectrum, fluorescence spectrum, spin-trapping epr technique, and laser photolysis technique. all complexes exhibit a red-shifted absorption spectrum, an increased absorbance above 600 nm, improved water solubility, and an enhanced affinity to ct dna over the parent ha. for ions that possess low-energy excited states, including ce3+, pr3+, nd3+, sm3+, eu3+, tb3+, dy3+, ho3+, er3+, tm3+, and yb3+, the corresponding complexes show undetectable or nearly undetectable fluorescence, a triplet excited-state lifetime, generation of ros, and photodamage in ct dna. in contrast, for ions that do not possess low-energy excited states, including sc3+, y3+, la3+, gd3+, and lu3+, the corresponding complexes exhibit higher photodamage abilities with ct dna with respect to ha, benefitting from both their comparable or even higher o-1(2) quantum yields and an electrostatic affinity that is higher for dna than ha.
WOS关键词	SINGLET OXYGEN ; ANTICANCER AGENTS ; LANTHANUM IONS ; THERAPY ; GENERATION ; CHELATION ; PHOTOSENSITIZATION ; PHOTOLYSIS ; PIGMENTS ; ESR
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000244735300036
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2382311
专题	中国科学院大学
通讯作者	Wang, Xuesong
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Organ Optoelect Funct Mat & Mol Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Zhanghua,Zhou, Jiahong,Zhang, Yan,et al. Photodynamic properties of hypocrellin a, complexes with rare earth trivalent ions: role of the excited state energies of the metal ions[J]. Journal of physical chemistry b,2007,111(10):2688-2696.
APA	Zeng, Zhanghua.,Zhou, Jiahong.,Zhang, Yan.,Qiao, Rui.,Xia, Shengqin.,...&Zhang, Baowen.(2007).Photodynamic properties of hypocrellin a, complexes with rare earth trivalent ions: role of the excited state energies of the metal ions.Journal of physical chemistry b,111(10),2688-2696.
MLA	Zeng, Zhanghua,et al."Photodynamic properties of hypocrellin a, complexes with rare earth trivalent ions: role of the excited state energies of the metal ions".Journal of physical chemistry b 111.10(2007):2688-2696.

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