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	Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b
	Sun, Cheng; Zhang, Fang; Ge, Xinjian; Yan, Tingting; Chen, Xingmiao; Shi, Xianglin; Zhai, Qiwei
刊名	Cell metabolism
	2007-10-01
卷号	6期号:4页码:307-319
ISSN号	1550-4131
DOI	10.1016/j.cmet.2007.08.014
通讯作者	Zhai, qiwei(qwzhai@sibs.ac.cn)
英文摘要	Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes. sirt1 has been reported to be involved in the processes of glucose metabolism and insulin secretion. however, whether sirt1 is directly involved in insulin sensitivity is still largely unknown. here we show that sirt1 is down-regulated in insulin-resistant cells and tissues and that knockdown or inhibition of sirt1 induces insulin resistance. furthermore, increased expression of sirt1 improved insulin sensitivity, especially under insulin-resistant conditions. similarly, resveratrol, a sirt1 activator, enhanced insulin sensitivity in vitro in a sirt1-dependent manner and attenuated high-fat-diet-induced insulin resistance in vivo at a dose of 2.5 mg/kg/day. further studies demonstrated that the effect of sirt1 on insulin resistance is mediated by repressing ptp1b transcription at the chromatin level. taken together, the finding that sirt1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes.
WOS关键词	PROTEIN-TYROSINE PHOSPHATASES ; PANCREATIC BETA-CELLS ; CALORIC RESTRICTION ; GLUCOSE ; RESVERATROL ; MICE ; KINASE ; FAMILY ; DEACETYLASES ; OBESITY
WOS研究方向	Cell Biology ; Endocrinology & Metabolism
WOS类目	Cell Biology ; Endocrinology & Metabolism
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000249929000009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2381462
专题	中国科学院大学
通讯作者	Zhai, Qiwei
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Sun, Cheng,Zhang, Fang,Ge, Xinjian,et al. Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b[J]. Cell metabolism,2007,6(4):307-319.
APA	Sun, Cheng.,Zhang, Fang.,Ge, Xinjian.,Yan, Tingting.,Chen, Xingmiao.,...&Zhai, Qiwei.(2007).Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b.Cell metabolism,6(4),307-319.
MLA	Sun, Cheng,et al."Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b".Cell metabolism 6.4(2007):307-319.

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