| Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase | |
| Zhao, Wen-Hua; Gao, Chunchun; Zhang, Ying-Xia; Tian, Wei-Xi | |
| 刊名 | Journal of enzyme inhibition and medicinal chemistry
 |
| 2007 | |
| 卷号 | 22期号:4页码:501-510 |
| 关键词 | Fatty acid synthase Enzyme inhibition Antitumor Aceraceae Kinetics |
| ISSN号 | 1475-6366 |
| DOI | 10.1080/14756360701306180 |
| 通讯作者 | Zhang, ying-xia(zhangyue@ccmu.edu.cn) |
| 英文摘要 | Fatty acid synthase ( fas) is a very significant lipogenic enzyme participating in energy metabolism in vivo and has been reported as a potential new therapeutic target for cancer treatment. the extracts from sixteen aceraceae were prepared to assay their inhibitory activities against duck liver fas and their correlated antitumor bioactivity. their inhibition of fas was composed of a reversible fast-binding inhibition, by which 0.41 mu g/ml of the a. campestre extract inhibits 50% fas activity, and an irreversible slow-binding inhibition with inactivation rate constants, k(obs), ranging between 1.5 x 10(-3) and 10.6 x 10(-3) min(-1). three aceraceae extracts were selected from their smaller ic50 values to study different type of inhibitions against the three substrates in the fas overall reaction. as compared with other reported fas inhibitors including egcg with regard to inhibition constant and ic50 value, the extracts appeared to be more efficient inhibitors, and exhibited a considerable inhibition against the growth of five types of cancer cells ( china patent application number 200610088901.6), which may be related to the inhibition of lipogenesis in these cells. |
| WOS关键词 | BREAST-CANCER CELLS ; ACER-MONO LEAVES ; NATURAL INHIBITOR ; PROSTATE-CANCER ; EPIGALLOCATECHIN GALLATE ; STILBENE GLYCOSIDES ; THERAPEUTIC TARGET ; ANTITUMOR-ACTIVITY ; CHICKEN LIVER ; EXPRESSION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000248489700017 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2381296 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Ying-Xia |
| 作者单位 | 1.Capital Med Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100069, Peoples R China 2.Harbin Commercial Univ, Dept Pharm, Harbin 150076, Peoples R China 3.Capital Med Univ, Lab Liver Protect & Regulat, Beijing 100069, Peoples R China 4.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wen-Hua,Gao, Chunchun,Zhang, Ying-Xia,et al. Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase[J]. Journal of enzyme inhibition and medicinal chemistry,2007,22(4):501-510. |
| APA | Zhao, Wen-Hua,Gao, Chunchun,Zhang, Ying-Xia,&Tian, Wei-Xi.(2007).Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase.Journal of enzyme inhibition and medicinal chemistry,22(4),501-510. |
| MLA | Zhao, Wen-Hua,et al."Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase".Journal of enzyme inhibition and medicinal chemistry 22.4(2007):501-510. |
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