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	Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model
	Sun, Wenjie1,3; Lin, Hang1; Xie, Hua2; Chen, Bing1; Zhao, Wenxue1; Han, Qianqian1; Zhao, Yannan1; Xiao, Zhifeng1; Dai, Jianwu1
刊名	Growth factors
	2007-10-01
卷号	25期号:5页码:309-318
关键词	Pdgf-bb Collagen-binding domain Ulcer healing Angiogenesis
ISSN号	0897-7194
DOI	10.1080/08977190701803885
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Studies have shown that exogenous platelet-derived growth factor-bb (pdgf-bb) could accelerate the ulcer healing, but the lack of efficient growth factor delivery system limits its clinical application. our previous work has demonstrated that the native human pdgf-bb was added a collagen-binding domain (cbd), tkktlrt, to develop a collagen-based pdgf targeting delivery system. here, we showed that this cbd-fused pdgf-bb (cbd-pdgf) could bind to collagen membrane efficiently. we used the rabbit dermal ischemic ulcer model to study the effects of cbd-pdgf loaded on collagen membranes. results revealed that this system maintained a higher concentration and stronger bioactivity of pdgf-bb on the collagen membranes and promoted the re-epithelialization of dermal ulcer wounds, the collagen deposition, and the formation of capillary lumens within the newly formed tissue area. it demonstrated that collagen membranes loaded with collagen-targeting human pdgf-bb could effectively promote ulcer healing.
WOS关键词	PHASE-I TRIAL ; GROWTH-FACTOR ; MOLECULAR-MECHANISMS ; TISSUE-REPAIR ; MATRIX ; SAFETY ; H5.020CMV.PDGF-B ; REGENERATION ; TRANSDUCTION ; FIBROBLASTS
WOS研究方向	Cell Biology ; Endocrinology & Metabolism
WOS类目	Cell Biology ; Endocrinology & Metabolism
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000253316800002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380531
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Kunming Med Coll, Yunnan 650031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Sun, Wenjie,Lin, Hang,Xie, Hua,et al. Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model[J]. Growth factors,2007,25(5):309-318.
APA	Sun, Wenjie.,Lin, Hang.,Xie, Hua.,Chen, Bing.,Zhao, Wenxue.,...&Dai, Jianwu.(2007).Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model.Growth factors,25(5),309-318.
MLA	Sun, Wenjie,et al."Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model".Growth factors 25.5(2007):309-318.

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