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	Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta
	Sun, Wenjie; Lin, Hang; Chen, Bing; Zhao, Wenxue; Zhao, Yannan; Dai, Jianwu
刊名	Journal of biomedical materials research part a
	2007-12-15
卷号	83a期号:4页码:1054-1061
关键词	Collagen-binding domain Genetic engineering Nerve growth factor Targeting delivery system
ISSN号	1549-3296
DOI	10.1002/jbm.a.31417
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Nerve growth factor (ngf) plays a critical role in neuronal development and regeneration. however, the lack of efficient ngf delivery system limits its clinical application. we reported that a peptide deduced from collagenase, tkktlrt, fused with ngf-beta could develop a collagen based ngf targeting delivery system. our results showed that this peptide could allow fused ngf-beta bind to collagen specifically. in addition, we found that the polypeptide could result in a 2.3-fold increase in the expression level and a significant improvement of bioactivity of fused ngf-beta. in the in vivo function study, collagen membranes loaded with the collagen binding ngf enhanced the nerve growth. thus, the targeting wound repair system could be important for the repair of peripheral nerve injury. (c) 2007 wiley periodicals, inc.
WOS关键词	ESCHERICHIA-COLI ; NEUROTROPHIC FACTORS ; FUSION PROTEINS ; BINDING ; REGENERATION ; EXPRESSION ; IMPLANTATION ; SOLUBILITY ; NEURONS ; MEMORY
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	WILEY-LISS
WOS记录号	WOS:000251267700018
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380403
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Sun, Wenjie,Lin, Hang,Chen, Bing,et al. Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta[J]. Journal of biomedical materials research part a,2007,83a(4):1054-1061.
APA	Sun, Wenjie,Lin, Hang,Chen, Bing,Zhao, Wenxue,Zhao, Yannan,&Dai, Jianwu.(2007).Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta.Journal of biomedical materials research part a,83a(4),1054-1061.
MLA	Sun, Wenjie,et al."Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta".Journal of biomedical materials research part a 83a.4(2007):1054-1061.

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