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	A complete mitochondrial genome sequence of the wild two-humped camel (camelus bactrianus ferus): an evolutionary history of camelidae
	Cui, Peng; Ji, Rimutu; Ding, Feng; Qi, Dan; Gao, Hongwei; Meng, He; Yu, Jun; Hu, Songnian; Zhang, Heping
刊名	Bmc genomics
	2007-07-18
卷号	8页码:10
ISSN号	1471-2164
DOI	10.1186/1471-2164-8-241
通讯作者	Hu, songnian(husn@genomics.org.cn)
英文摘要	Background: the family camelidae that evolved in north america during the eocene survived with two distinct tribes, camelini and lamini. to investigate the evolutionary relationship between them and to further understand the evolutionary history of this family, we determined the complete mitochondrial genome sequence of the wild two-humped camel (camelus bactrianus ferus), the only wild survivor of the old world camel. results: the mitochondrial genome sequence ( 16,680 bp) from c. bactrianus ferus contains 13 protein-coding, two rrna, and 22 trna genes as well as a typical control region; this basic structure is shared by all metazoan mitochondrial genomes. its protein-coding region exhibits codon usage common to all mammals and possesses the three cryptic stop codons shared by all vertebrates. c. bactrianus ferus together with the rest of mammalian species do not share a triplet nucleotide insertion (gcc) that encodes a proline residue found only in the nd1 gene of the new world camelid lama pacos. this lineage-specific insertion in the l. pacos mtdna occurred after the split between the old and new world camelids suggests that it may have functional implication since a proline insertion in a protein backbone usually alters protein conformation significantly, and nd1 gene has not been seen as polymorphic as the rest of nd family genes among camelids. our phylogenetic study based on complete mitochondrial genomes excluding the control region suggested that the divergence of the two tribes may occur in the early miocene; it is much earlier than what was deduced from the fossil record (11 million years). an evolutionary history reconstructed for the family camelidae based on cytb sequences suggested that the split of bactrian camel and dromedary may have occurred in north america before the tribe camelini migrated from north america to asia. conclusion: molecular clock analysis of complete mitochondrial genomes from c. bactrianus ferus and l. pacos suggested that the two tribes diverged from their common ancestor about 25 million years ago, much earlier than what was predicted based on fossil records.
WOS关键词	DNA ; REPLICATION ; ALIGNMENT
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000248482000001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380386
专题	中国科学院大学
通讯作者	Hu, Songnian
作者单位	1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Geome Informat & Sci, Beijing, Peoples R China 2.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Dairy Biotechnol & Engn, Hohhot, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200030, Peoples R China
推荐引用方式 GB/T 7714	Cui, Peng,Ji, Rimutu,Ding, Feng,et al. A complete mitochondrial genome sequence of the wild two-humped camel (camelus bactrianus ferus): an evolutionary history of camelidae[J]. Bmc genomics,2007,8:10.
APA	Cui, Peng.,Ji, Rimutu.,Ding, Feng.,Qi, Dan.,Gao, Hongwei.,...&Zhang, Heping.(2007).A complete mitochondrial genome sequence of the wild two-humped camel (camelus bactrianus ferus): an evolutionary history of camelidae.Bmc genomics,8,10.
MLA	Cui, Peng,et al."A complete mitochondrial genome sequence of the wild two-humped camel (camelus bactrianus ferus): an evolutionary history of camelidae".Bmc genomics 8(2007):10.

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