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	The role of intracellular amyloid beta in alzheimer's disease
	Li, Meng; Chen, Liying; Lee, Daniel Hong Seng; Yu, Long-Chuan; Zhang, Yan
刊名	Progress in neurobiology
	2007-10-01
卷号	83期号:3页码:131-139
关键词	Alzheimer's disease Amyloid p peptide Neurotoxicity Neuronal loss
ISSN号	0301-0082
DOI	10.1016/j.pneurobio.2007.08.002
通讯作者	Yu, long-chuan(yulc@pku.edu.cn)
英文摘要	Extracellular amyloid beta (a beta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of alzheimer's disease (ad) pathology. like many other misfolded proteins identified in neurodegenerative disorders, a beta also accumulates inside the ad neurons. this intracellular a beta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of a beta in ad. therapeutics targeting intracellular a beta could be effective treatment for ad. (c) 2007 elsevier ltd. all rights reserved.
WOS关键词	INTRANEURONAL-A-BETA ; INCLUSION-BODY MYOSITIS ; ELECTRON-MICROSCOPIC LOCALIZATION ; TRANSGENIC MOUSE MODEL ; APOPTOTIC CELL-DEATH ; PRECURSOR PROTEIN ; ENDOPLASMIC-RETICULUM ; PLAQUE-FORMATION ; HUMAN NEURONS ; DOWN-SYNDROME
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000250978100001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380295
专题	中国科学院大学
通讯作者	Yu, Long-Chuan
作者单位	1.Peking Univ, Coll Life Sci, Lab Neurobiol, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 2.Biogen Inc, Cambridge, MA 02142 USA
推荐引用方式 GB/T 7714	Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,et al. The role of intracellular amyloid beta in alzheimer's disease[J]. Progress in neurobiology,2007,83(3):131-139.
APA	Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,Yu, Long-Chuan,&Zhang, Yan.(2007).The role of intracellular amyloid beta in alzheimer's disease.Progress in neurobiology,83(3),131-139.
MLA	Li, Meng,et al."The role of intracellular amyloid beta in alzheimer's disease".Progress in neurobiology 83.3(2007):131-139.

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