| Regulatory cd4(+)cd25(+) t-cells are controlled by multiple pathways at multiple levels | |
| Qu, Yanyan; Zhao, Yong | |
| 刊名 | International reviews of immunology
 |
| 2007-05-01 | |
| 卷号 | 26期号:3-4页码:145-160 |
| 关键词 | Cd4(+)cd25(+) Foxp3 Tolerance Treg cells |
| ISSN号 | 0883-0185 |
| DOI | 10.1080/08830180701365917 |
| 通讯作者 | Zhao, yong(zhaoy@ioz.ac.cn) |
| 英文摘要 | Cd4(+)-cd25(+) regulatory t-cells (treg cells) are an important subset off-cells that functions to negatively control immune responses to self or non-self antigens. depletion of cd4(+) cd25(+) treg cells leads to the occurrence of lymphoproliferatiue autoimmune diseases in animals and humans. therefbre, cd4(+) cd25(+) treg cells must be tightly regulated in the physiologic situation. in this article, we try to summarize the regulating pathways of the development, survival, and function of cd4(+)cd25(+) treg cells at multiple levels and multiple pathways, including the dendritic cells, costimulatory signals, cytokines, as well as intracellular signals. |
| WOS关键词 | IMMUNOLOGICAL SELF-TOLERANCE ; TRANSCRIPTION FACTOR FOXP3 ; GROWTH-FACTOR-BETA ; IN-VIVO EXPANSION ; DENDRITIC CELLS ; TGF-BETA ; CUTTING EDGE ; B7/CD28 COSTIMULATION ; TRANSPLANT TOLERANCE ; INTERLEUKIN (IL)-2 |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000247737900002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2380274 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Yong |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100080, Peoples R China 2.Grad Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68182 USA |
| 推荐引用方式 GB/T 7714 | Qu, Yanyan,Zhao, Yong. Regulatory cd4(+)cd25(+) t-cells are controlled by multiple pathways at multiple levels[J]. International reviews of immunology,2007,26(3-4):145-160. |
| APA | Qu, Yanyan,&Zhao, Yong.(2007).Regulatory cd4(+)cd25(+) t-cells are controlled by multiple pathways at multiple levels.International reviews of immunology,26(3-4),145-160. |
| MLA | Qu, Yanyan,et al."Regulatory cd4(+)cd25(+) t-cells are controlled by multiple pathways at multiple levels".International reviews of immunology 26.3-4(2007):145-160. |
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