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	Carbon nanotube-modified carbon fiber microelectrodes for in vivo voltammetric measurement of ascorbic acid in rat brain
	Zhang, Meining; Liu, Kun; Xiang, Ling; Lin, Yuqing; Su, Lei; Mao, Lanquin
刊名	Analytical chemistry
	2007-09-01
卷号	79期号:17页码:6559-6565
ISSN号	0003-2700
DOI	10.1021/ac0705871
通讯作者	Mao, lanquin(lqmao@iccas.ac.cn)
英文摘要	This study demonstrates a new electrochemical method for in vivo measurements of ascorbic acid (aa) in rat brain with multiwalled carbon nanotube (mwnt)-modified carbon fiber microelectrodes (cfmes) based on the electrochemical property of mwnts for facilitating aa oxidation. cyclic voltammetry results indicate that the prepared mwnt-modified cfmes possess a marked electrocatalytic activity toward aa oxidation and can be used for its selective measurement in the presence of other kinds of electroactive species coexisting in rat brain, such as 3,4-dihydroxyphenylacetic acid, uric acid, and 5-hydroxytzyptamine. the selectivity of the mwnt-modified cfmes toward aa measurement is further studied in vivo by exogenously infusing ascorbate oxidase into the brain, and the results confirm that the prepared electrodes are selective and can thus be used for reliable in vivo measurements of aa in rat brain, combined with their good stability during in vivo measurements. the basal level of striatum aa is determined to be 0.20 +/- 0.05 mm (n = 3). the application of the voltammetric method with the mwnt-modified cfmes is preliminarily demonstrated for in vivo observation of homeostatic regulation of striatum aa with exogenous infusion of aa into the brain.
WOS关键词	ELECTROANALYTICAL APPLICATIONS ; ELECTROCHEMICAL PRETREATMENT ; INVIVO ELECTROCHEMISTRY ; EXTRACELLULAR FLUID ; MERCURY-ELECTRODE ; OXIDATION ; BIOSENSORS ; MECHANISM ; OXIDASE ; SENSORS
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000249242900024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2380165
专题	中国科学院大学
通讯作者	Mao, Lanquin
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China 2.CAS, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Meining,Liu, Kun,Xiang, Ling,et al. Carbon nanotube-modified carbon fiber microelectrodes for in vivo voltammetric measurement of ascorbic acid in rat brain[J]. Analytical chemistry,2007,79(17):6559-6565.
APA	Zhang, Meining,Liu, Kun,Xiang, Ling,Lin, Yuqing,Su, Lei,&Mao, Lanquin.(2007).Carbon nanotube-modified carbon fiber microelectrodes for in vivo voltammetric measurement of ascorbic acid in rat brain.Analytical chemistry,79(17),6559-6565.
MLA	Zhang, Meining,et al."Carbon nanotube-modified carbon fiber microelectrodes for in vivo voltammetric measurement of ascorbic acid in rat brain".Analytical chemistry 79.17(2007):6559-6565.

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