Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation

	Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation
	Li, Wei 2; Liu, Yong 1; Zhang, Jiang-Wei 1; Ai, Chun-Zhi 2; Xiang, Nan 3; Liu, Hui-Xin 2; Yang, Ling 1
刊名	archives of pharmacal research
	2009
卷号	32 期号:1 页码:49-57
关键词	Ginsenosides Structure-activity relationship Anti-androgen-independent prostate cancer In vitro Intestinal bacterial metabolites
通讯作者	杨凌
产权排序	1;1
英文摘要	treatment of androgen-independent prostate cancer (aipc) remains unsatisfactory. in our present experiment, natural occurring ginsenosides (nogs) and intestinal bacterial metabolites (ibms) were employed to investigate their anti-aipc cell growth activity using pc-3 cells. our results showed that the ibms exerted more portent anti-aipc activity than nogs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in aipc pc-3 cells. the increase of logp and decrease of c-6 steric hindrance, which were caused by deglycosylation by intestinal bacteria, may be the reason for the higher anti-aipc activity of ibms.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	pharmacology & pharmacy
关键词[WOS]	intestinal bacterial metabolite ; human cytochrome-p450 enzymes ; plant glycosides ; panax-ginseng ; cell-line ; apoptosis ; proliferation ; mitochondria ; activation ; saponins
收录类别	SCI
原文出处	false
语种	英语
WOS记录号	WOS:000262851700007
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/101529]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Dalian Med Univ, Dalian 116027, Peoples R China
推荐引用方式 GB/T 7714	Li, Wei,Liu, Yong,Zhang, Jiang-Wei,et al. Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation[J]. archives of pharmacal research,2009,32(1):49-57.
APA	Li, Wei.,Liu, Yong.,Zhang, Jiang-Wei.,Ai, Chun-Zhi.,Xiang, Nan.,...&Yang, Ling.(2009).Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation.archives of pharmacal research,32(1),49-57.
MLA	Li, Wei,et al."Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation".archives of pharmacal research 32.1(2009):49-57.