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	Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide
	Zhou, Qiong; Meng, Dan; Yan, Bing; Jiang, Bing-Hua; Fang, Jing
刊名	Febs letters
	2006-10-02
卷号	580期号:22页码:5161-5166
关键词	Insulin-like growth factor Epidermal growth factor receptor Hydrogen peroxide
ISSN号	0014-5793
DOI	10.1016/j.febslet.2006.08.068
通讯作者	Fang, jing(jfang@sibs.ac.cn)
英文摘要	Insulin-like growth factor (igf-1) plays an important role in prostate cancer development. recent studies suggest that igf-1 has mitogenic action through epidermal growth factor receptor (egfr). however, the mechanism remains largely unknown. here, we demonstrated in prostate cancer du145 cells that igf-1 induced egfr transactivation, leading to erk activation. matrix metalloproteinase-mediated shedding of heparinbinding egf is involved in this process. antioxidants and catalase inhibited igf-1-stimulated egfr phosphorylation, indicating that h2o2 is required for egfr activation. however, exogenous h2o2 did not activate egfr or igf-1r in du145 cells. igf-1 did not induced production of h2o2 in du145 cells. our results suggest that transactivation of egfr by igf-1 requires basal intracellular h2o2 in du145 cells. (c) 2006 federation of european biochemical societies. published by elsevier b.v. all rights reserved.
WOS关键词	FACTOR-I ; TYROSINE KINASE ; CELLULAR-RESPONSES ; SIGNALING PATHWAYS ; CELLS ; PHOSPHORYLATION ; PROSTATE ; EGF ; ACTIVATION ; GENERATION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000241044400007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379874
专题	中国科学院大学
通讯作者	Fang, Jing
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China 2.W Virginia Univ, MBR Canc Ctr, Morgantown, WV 26505 USA
推荐引用方式 GB/T 7714	Zhou, Qiong,Meng, Dan,Yan, Bing,et al. Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide[J]. Febs letters,2006,580(22):5161-5166.
APA	Zhou, Qiong,Meng, Dan,Yan, Bing,Jiang, Bing-Hua,&Fang, Jing.(2006).Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide.Febs letters,580(22),5161-5166.
MLA	Zhou, Qiong,et al."Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide".Febs letters 580.22(2006):5161-5166.

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