Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide | |
Zhou, Qiong; Meng, Dan; Yan, Bing; Jiang, Bing-Hua; Fang, Jing | |
刊名 | Febs letters
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2006-10-02 | |
卷号 | 580期号:22页码:5161-5166 |
关键词 | Insulin-like growth factor Epidermal growth factor receptor Hydrogen peroxide |
ISSN号 | 0014-5793 |
DOI | 10.1016/j.febslet.2006.08.068 |
通讯作者 | Fang, jing(jfang@sibs.ac.cn) |
英文摘要 | Insulin-like growth factor (igf-1) plays an important role in prostate cancer development. recent studies suggest that igf-1 has mitogenic action through epidermal growth factor receptor (egfr). however, the mechanism remains largely unknown. here, we demonstrated in prostate cancer du145 cells that igf-1 induced egfr transactivation, leading to erk activation. matrix metalloproteinase-mediated shedding of heparinbinding egf is involved in this process. antioxidants and catalase inhibited igf-1-stimulated egfr phosphorylation, indicating that h2o2 is required for egfr activation. however, exogenous h2o2 did not activate egfr or igf-1r in du145 cells. igf-1 did not induced production of h2o2 in du145 cells. our results suggest that transactivation of egfr by igf-1 requires basal intracellular h2o2 in du145 cells. (c) 2006 federation of european biochemical societies. published by elsevier b.v. all rights reserved. |
WOS关键词 | FACTOR-I ; TYROSINE KINASE ; CELLULAR-RESPONSES ; SIGNALING PATHWAYS ; CELLS ; PHOSPHORYLATION ; PROSTATE ; EGF ; ACTIVATION ; GENERATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000241044400007 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2379874 |
专题 | 中国科学院大学 |
通讯作者 | Fang, Jing |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China 2.W Virginia Univ, MBR Canc Ctr, Morgantown, WV 26505 USA |
推荐引用方式 GB/T 7714 | Zhou, Qiong,Meng, Dan,Yan, Bing,et al. Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide[J]. Febs letters,2006,580(22):5161-5166. |
APA | Zhou, Qiong,Meng, Dan,Yan, Bing,Jiang, Bing-Hua,&Fang, Jing.(2006).Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide.Febs letters,580(22),5161-5166. |
MLA | Zhou, Qiong,et al."Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide".Febs letters 580.22(2006):5161-5166. |
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