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	Cf mediated g1 arrest is associated with induction of p27(kip1) and inhibition of cyclin d1 expression in human hepatoma hepg2 cells
	Ye, J; Wang, JZ
刊名	Hepatology research
	2006-06-01
卷号	35期号:2页码:88-95
关键词	Cf Hepatocellular carcinoma Cell differentiation Cell cycle Retinoic acid
ISSN号	1386-6346
DOI	10.1016/j.hepres.2006.02.007
通讯作者	Wang, jz(wangjz@ioz.ac.cn)
英文摘要	Cf is a kind of diterpenoid which was first isolated and purified from chinese tropical plants by our laboratory. our previous works have demonstrated it could inhibit the proliferation of several malignant tumor cell lines and stimulate them to differentiate to normal cells. in this article we investigated the effect of cf on human hepatocellulor carcinoma hepg2 cell viability, differentiation, cell cycle distribution and g1 cell cycle related genes expression. we also detected the effect of retinoic acid (ra) which was used as positive control and the effect of combination cf + ra. our data suggested that cf could be useful to induce growth arrest and differentiation in hepg2 cell lines, and could reverse the transformed phenotype. this anti-tumor effect was due to g i arrest in cell cycle which was associated with an increase of p27(kip1) and a decrease of cyclin d1 expression, so cf might be a useful targeted therapy strategy for hcc. results also showed ra has a different mechanism from cf on g1 arrest, and cf has not synergistic anti-tumor effect with ra on hepg2 treatment. (c) 2006 elsevier ireland ltd. all rights reserved.
WOS关键词	RETINOIC ACID RECEPTOR ; HEPATOCELLULAR-CARCINOMA ; TYROSINE AMINOTRANSFERASE ; SUPPRESS PROLIFERATION ; GROWTH-INHIBITION ; ALPHA-FETOPROTEIN ; ALL-TRANS ; DIFFERENTIATION ; PROTEIN ; CAMP
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000238585800004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379630
专题	中国科学院大学
通讯作者	Wang, JZ
作者单位	1.Chinese Acad Sci, Inst Zool, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ye, J,Wang, JZ. Cf mediated g1 arrest is associated with induction of p27(kip1) and inhibition of cyclin d1 expression in human hepatoma hepg2 cells[J]. Hepatology research,2006,35(2):88-95.
APA	Ye, J,&Wang, JZ.(2006).Cf mediated g1 arrest is associated with induction of p27(kip1) and inhibition of cyclin d1 expression in human hepatoma hepg2 cells.Hepatology research,35(2),88-95.
MLA	Ye, J,et al."Cf mediated g1 arrest is associated with induction of p27(kip1) and inhibition of cyclin d1 expression in human hepatoma hepg2 cells".Hepatology research 35.2(2006):88-95.

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