QQ客服 官方微博 反馈留言

	A novel computational method to predict transcription factor dna binding preference
	Qian, Ziliang; Cai, Yu-Dong; Li, Yixue
刊名	Biochemical and biophysical research communications
	2006-09-29
卷号	348期号:3页码:1034-1037
关键词	Transcription factor Transcription factor dna binding preference Nearest neighbor algorithm 0/1 system Jackknife cross-validation test Gene ontology
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2006.07.149
通讯作者	Cai, yu-dong(cyd@picb.ac.cn)
英文摘要	Transcription factor binds to sequence specific sites in regulatory region to control nearby gene's expression. it is termed as the major regulator of transcription. however, identifying dna binding preference of transcription factors systematically is still a challenge. by using the nearest neighbor algorithm, a novel computational approach was developed to predict transcription factor dna binding preference based on the gene ontology [m. ashburner, c.a. ball, j.a. blake, d. botstein, h. butler, j.m. cherry, a.p. davis, k. dolinski, s.s. dwight, j.t. eppig, m.a. harris, d.p. hill, l. issel-tarver, a. kasarskis, s. lewis, j.c. matese, j.e. richardson, m. ringwald, g.m. rubin, g. sherlock, gene ontology: tool for the unification of biology, nat. genet. 25 (2000) 25-29.] and 0/1 encoding system of nucleotide. the overall success rate of jackknife cross-validation test for our predictor reaches 76.6%, which indicates the dna binding preference is closely correlated with its biological functions and computational method developed in this contribution could be a powerful tool to investigate transcription factor dna binding preference, especially for those novel transcription factors with little prior knowledge on its dna binding preference. (c) 2006 elsevier inc. all rights reserved.
WOS关键词	FUNCTIONAL DOMAIN COMPOSITION ; HYBRIDIZATION SPACE ; GENE ONTOLOGY ; PROTEINS ; SITES ; RECOGNITION ; DISCOVERY ; FAMILY ; CODE ; GO
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000240166500035
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379515
专题	中国科学院大学
通讯作者	Cai, Yu-Dong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, MPG Partner Int Computat Biol, Beijing 100864, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Bioinformat Ctr, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Univ Manchester, Inst Sci & Technol, Dept Math, Manchester M60 1QD, Lancs, England 5.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China
推荐引用方式 GB/T 7714	Qian, Ziliang,Cai, Yu-Dong,Li, Yixue. A novel computational method to predict transcription factor dna binding preference[J]. Biochemical and biophysical research communications,2006,348(3):1034-1037.
APA	Qian, Ziliang,Cai, Yu-Dong,&Li, Yixue.(2006).A novel computational method to predict transcription factor dna binding preference.Biochemical and biophysical research communications,348(3),1034-1037.
MLA	Qian, Ziliang,et al."A novel computational method to predict transcription factor dna binding preference".Biochemical and biophysical research communications 348.3(2006):1034-1037.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。