| The anti-nociceptive effect of bmk as, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated na+ currents in primary afferent neurons | |
| Chen, Jin; Feng, Xing-Hua; Shi, Jian; Tan, Zhi-Yong; Bai, Zhan-Tao; Liu, Tong; Ji, Yong-Hua | |
| 刊名 | Peptides
 |
| 2006-09-01 | |
| 卷号 | 27期号:9页码:2182-2192 |
| 关键词 | Scorpion toxin Sodium channel Anti-nociception |
| ISSN号 | 0196-9781 |
| DOI | 10.1016/j.peptides.2006.03.026 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | In the present study, we investigated the anti-nociceptive effect and the underlying mechanism of bmk as, an active peptide purified from scorpion buthus martensi karsch. the results showed that bmk as can significantly relieve formalin-induced two-phase spontaneous flinching response and carrageenan-induced mechanical hyperalgesia. using the whole-cell patch-clamp recording, exposure of acutely isolated sensory neurons to 500 nm bmk as produced a one-fold decrease in the number of action potentials (aps) evoked by a ramp of depolarizing current. to investigate the mechanism of action of bmk as, isolated membrane current and ca2+ influx on rat primary sensory neurons were examined. bmk as produced insignificant effect on voltage-dependent i-k and kcl or caffeine-induced ca2+ influx, but caused remarkable suppressive effect on tetrodotoxin-resistant (ttx-r) and tetrodotoxin-sensitive (ttx-s) i-na. further experiments showed that bmk as reduced the peak ttx-r and ttx-s na+ conductance in a dose-dependent manner, prompted the voltage-dependent activation, and caused a negative shift of the steady-state inactivation of ttx-r and ttx-s i-na. thus, the present results indicate the anti-nociceptive response of bmk as may be ascribed to its specific modulation of voltage-gated na+ channels of sensory neurons. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | RAT SENSORY NEURONS ; BUTHUS-MARTENSI KARSCH ; ROOT GANGLION NEURONS ; SODIUM-CHANNELS ; SKELETAL-MUSCLE ; FORMALIN TEST ; PERIPHERAL-NERVE ; PAIN RESPONSE ; RECEPTOR ; TOXIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000240379800018 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2379365 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Physiol, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200436, Peoples R China 3.Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06520 USA |
| 推荐引用方式 GB/T 7714 | Chen, Jin,Feng, Xing-Hua,Shi, Jian,et al. The anti-nociceptive effect of bmk as, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated na+ currents in primary afferent neurons[J]. Peptides,2006,27(9):2182-2192. |
| APA | Chen, Jin.,Feng, Xing-Hua.,Shi, Jian.,Tan, Zhi-Yong.,Bai, Zhan-Tao.,...&Ji, Yong-Hua.(2006).The anti-nociceptive effect of bmk as, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated na+ currents in primary afferent neurons.Peptides,27(9),2182-2192. |
| MLA | Chen, Jin,et al."The anti-nociceptive effect of bmk as, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated na+ currents in primary afferent neurons".Peptides 27.9(2006):2182-2192. |
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