| Prediction of trans-antisense transcripts in arabidopsis thaliana | |
| Wang, Huan; Chua, Nam-Hai; Wang, Xiu-Jie | |
| 刊名 | Genome biology
 |
| 2006 | |
| 卷号 | 7期号:10页码:11 |
| ISSN号 | 1474-760X |
| DOI | 10.1186/gb-2006-7-10-r92 |
| 通讯作者 | Wang, xiu-jie(xjwang@genetics.ac.cn) |
| 英文摘要 | Background: natural antisense transcripts (nats) are coding or non-coding rnas with sequence complementarity to other transcripts (sense transcripts). these rnas could potentially regulate the expression of their sense partner(s) at either the transcriptional or post-transcriptional level. experimental and computational methods have demonstrated the widespread occurrence of nats in eukaryotes. however, most previous studies only focused on cis-nats with little attention being paid to nats that originate in trans. results: we have performed a genome-wide screen of trans-nats in arabidopsis thaliana and identified 1,320 putative trans-nat pairs. an rna annealing program predicted that most trans-nats could form extended double-stranded rna duplexes with their sense partners. among trans-nats with available expression data, more than 85% were found in the same tissue as their sense partners; of these, 67% were found in the same cell as their sense partners at comparable expression levels. for about 60% of arabidopsis trans-nats, orthologs of at least one transcript of the pair also had trans-nat partners in either populus trichocarpa or oryza sativa. the observation that 430 transcripts had both putative cis- and trans-nats implicates multiple regulations by antisense transcripts. the potential roles of trans-nats in inducing post-transcriptional gene silencing and in regulating alternative splicing were also examined. conclusion: the arabidopsis transcriptome contains a fairly large number of trans-nats, whose possible functions include silencing of the corresponding sense transcripts or altering their splicing patterns. the interlaced relationships observed in some cis- and trans-nat pairs suggest that antisense transcripts could be involved in complex regulatory networks in eukaryotes. |
| WOS关键词 | DOUBLE-STRANDED-RNA ; GENE ; EXPRESSION ; GENOME ; IDENTIFICATION ; INTERFERENCE ; METHYLATION ; SEQUENCES |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | BIOMED CENTRAL LTD |
| WOS记录号 | WOS:000242516200010 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2379059 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Xiu-Jie |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Plant Genom, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100101, Peoples R China 3.Rockefeller Univ, Plant Mol Biol Lab, New York, NY 10021 USA |
| 推荐引用方式 GB/T 7714 | Wang, Huan,Chua, Nam-Hai,Wang, Xiu-Jie. Prediction of trans-antisense transcripts in arabidopsis thaliana[J]. Genome biology,2006,7(10):11. |
| APA | Wang, Huan,Chua, Nam-Hai,&Wang, Xiu-Jie.(2006).Prediction of trans-antisense transcripts in arabidopsis thaliana.Genome biology,7(10),11. |
| MLA | Wang, Huan,et al."Prediction of trans-antisense transcripts in arabidopsis thaliana".Genome biology 7.10(2006):11. |
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