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	Magnesium lithospermate b ameliorates renal cortical microperfusion in rats
	Chen, CG; Wang, YP
刊名	Acta pharmacologica sinica
	2006-02-01
卷号	27期号:2页码:217-222
关键词	Magnesium lithospermate b Hemodynamics Renal blood flow Renal cortical microperfusion
ISSN号	1671-4083
DOI	10.1111/j.1745-7254.2006.00225.x
通讯作者	Wang, yp()
英文摘要	Aim: to investigate the effects of magnesium lithospermate b (mlb) isolated from salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in sprague-dawley rats. methods: mlb (10, 30, and 60 mg/kg) was injected intravenously and renal blood flow (rbf), renal cortical microperfusion (rcm), and systemic hemodynamic function parameters including heart rate (hr), mean arterial pressure (map), left ventricular systolic pressure (lvsp), left ventricular end-diastolic pressure (lvedp), and maximal velocity of pressure increase (dp/dt(max)) were measured for 45 min after administration. results: intravenous mlb at doses of 10, 30, and 60 mg/kg increased rcm significantly, but had no obvious effects on rbf or systemic hemodynamics. the effect of mlb on rcm reached its peak 15 min after injection and returned to baseline after 45 min. up to 60 mg/kg mlb increased rcm by 62.4%+/- 20.2% (changes from baseline, p < 0.01), whereas rbf (3.7%+/- 9.7% vs baseline) and renal vascular resistance (-1.4%+/- 9.1% vs baseline) did not obviously change. conclusion: these results indicate that mlb ameliorates renal microcirculation in a dose-dependent manner, which may be related to the renoprotective effects of mlb.
WOS关键词	NITRIC-OXIDE ; VASCULAR-RESISTANCE ; SALVIA-MILTIORRHIZA ; OXYGEN RADICALS ; FAILURE ; PROSTAGLANDINS ; SUPEROXIDE ; RESPONSES ; KIDNEY ; INJURY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
语种	英语
出版者	BLACKWELL PUBLISHING
WOS记录号	WOS:000234794700013
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378773
专题	中国科学院大学
通讯作者	Wang, YP
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, CG,Wang, YP. Magnesium lithospermate b ameliorates renal cortical microperfusion in rats[J]. Acta pharmacologica sinica,2006,27(2):217-222.
APA	Chen, CG,&Wang, YP.(2006).Magnesium lithospermate b ameliorates renal cortical microperfusion in rats.Acta pharmacologica sinica,27(2),217-222.
MLA	Chen, CG,et al."Magnesium lithospermate b ameliorates renal cortical microperfusion in rats".Acta pharmacologica sinica 27.2(2006):217-222.

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