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	A delivery strategy for rotenone microspheres in an animal model of parkinson's disease
	Huang, J; Liu, HQ; Gu, WW; Yan, Z; Xu, ZH; Yang, YX; Zhu, XZ; Li, YP
刊名	Biomaterials
	2006-02-01
卷号	27期号:6页码:937-946
关键词	Parkinson's disease Rotenone Microspheres Plga Drug delivery
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2005.07.005
通讯作者	Li, yp()
英文摘要	In order to study the pathogenesis of parkinson's disease (pd), and explore therapeutic drug or approaches, the accurate animal model of pd with inexpensive, biocompatible and convenient administration was necessary. the aim of the present work was to investigate a delivery strategy for rotenone microspheres in an animal model of pd. the rotenone microspheres were prepared by solvent evaporation technique. the rotenone microspheres showed high entrapment efficiency (97.4 +/- 2.2%) with particle size about 100 mu m. in vitro release of rotenone microspheres demonstrated different profiles from medium with different ph or concentration of isopropyl alcohol. the most consistent medium with in vivo rotenone levels in rat plasma was pbs (ph 5.8) with 20% isopropyl alcohol, and the cumulated release amount of rotenone over 30 days was 95.4% in it. the rotenone microspheres (90 mg/kg) produced typical pd symptoms in rats, for example, the cataleptic behavior test demonstrated a obviously prolonged descent latency compared with control animals after administration, and the tyrosine hydroxylase (th) immunohistochemistry tests showed typical histological evidence of selective degeneration of the nigrostriatal dopaminergic system (striatum and substantia nigra) in rotenone micro spheres-treated rats. in addition, this delivery system for rotenone model showed many noticeable advantages such as inexpensive, biocompatible and expedient administration by direct subcutaneous injection. this information suggested that rotenone microspheres as a delivery strategy for setting up an ideal animal model of pd was feasible. (c) 2005 elsevier ltd. all rights reserved.
WOS关键词	IN-VITRO RELEASE ; SYMPTOMS ; RATS ; FTIR
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000234095800014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378732
专题	中国科学院大学
通讯作者	Li, YP
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Huang, J,Liu, HQ,Gu, WW,et al. A delivery strategy for rotenone microspheres in an animal model of parkinson's disease[J]. Biomaterials,2006,27(6):937-946.
APA	Huang, J.,Liu, HQ.,Gu, WW.,Yan, Z.,Xu, ZH.,...&Li, YP.(2006).A delivery strategy for rotenone microspheres in an animal model of parkinson's disease.Biomaterials,27(6),937-946.
MLA	Huang, J,et al."A delivery strategy for rotenone microspheres in an animal model of parkinson's disease".Biomaterials 27.6(2006):937-946.

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