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	Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein swedish mutation overexpressing sh-sy5y cells
	Zhang, J.; Mori, A.; Chen, Q.; Zhao, B.
刊名	Neuroscience
	2006-11-17
卷号	143期号:1页码:63-72
关键词	Alzheimer's disease Copper Beta-amyloid Papaya
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2006.07.023
通讯作者	Zhao, b.(zhaobl@sun5.ibp.ac.cn)
英文摘要	Recent studies indicate that the deposition of beta-amyloid (a beta) is related in the pathogenesis of alzheimer's disease (ad), but the underlying mechanism is still not clear. the abnormal interactions of a beta with metal ions such as copper are implicated in the process of a beta deposition and oxidative stress in ad brains. in the present study, we established a new ad model, using which we found that copper triggered the a beta neurotoxicity in sh-sy5y cells overexpressing the swedish mutant form of human app (appsw) in a concentration dependent manner. fermented papaya preppration (fpp) has shown high free radical scavenging ability in vivo and in vitro. fpp post-treatment increased cell viability and decreased the intracellular [ca2+](i), reactive oxygen species (ros) generation such as hydroxyl free radical and superoxide anion and nitric oxide (no) accumulation in the cell. our results also show that fpp prevents the cell apoptosis through bax/bcl-2 sensitive pathway. (c) 2006 ibro. published by elsevier ltd. all rights reserved.
WOS关键词	SUPEROXIDE-DISMUTASE ACTIVITY ; NITRIC-OXIDE SYNTHASE ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; FREE-RADICALS ; A-BETA ; HYDROGEN-PEROXIDE ; NEURONAL CULTURES ; INDUCED APOPTOSIS ; SENILE PLAQUES
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000242109300007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378610
专题	中国科学院大学
通讯作者	Zhao, B.
作者单位	1.Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Okayama Univ, Sch Med, Okayama 700, Japan 4.Salk Inst Biol Studies, La Jolla, CA 92037 USA
推荐引用方式 GB/T 7714	Zhang, J.,Mori, A.,Chen, Q.,et al. Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein swedish mutation overexpressing sh-sy5y cells[J]. Neuroscience,2006,143(1):63-72.
APA	Zhang, J.,Mori, A.,Chen, Q.,&Zhao, B..(2006).Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein swedish mutation overexpressing sh-sy5y cells.Neuroscience,143(1),63-72.
MLA	Zhang, J.,et al."Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein swedish mutation overexpressing sh-sy5y cells".Neuroscience 143.1(2006):63-72.

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