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	Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in arabidopsis
	Zheng, Wenguang; Zhai, Qingzhe; Sun, Jiaqiang; Li, Chang-Bao; Zhang, Lei; Li, Hongmei; Zhang, Xiaoli; Li, Shuyu; Xu, Yingxiu; Jiang, Hongling
刊名	Plant physiology
	2006-08-01
卷号	141期号:4页码:1400-1413
ISSN号	0032-0889
DOI	10.1104/pp.106.080390
通讯作者	Li, chuanyou(cyli@genetics.ac.cn)
英文摘要	Bestatin, a potent inhibitor of some aminopeptidases, was shown previously to be a powerful inducer of wound-response genes in tomato ( lycopersicon esculentum). here, we present several lines of evidence showing that bestatin specifically activates jasmonic acid (ja) signaling in plants. first, bestatin specifically activates the expression of ja-inducible genes in tomato and arabidopsis ( arabidopsis thaliana). second, the induction of ja-responsive genes by bestatin requires the coi1-dependent ja-signaling pathway, but does not depend strictly on ja biosynthesis. third, microarray analysis using arabidopsis whole-genome chip demonstrates that the gene expression profile of bestatin-treated plants is similar to that of ja-treated plants. fourth, bestatin promotes a series of ja-related developmental phenotypes. taken together, the unique action mode of bestatin in regulating ja-signaled processes leads us to the hypothesis that bestatin exerts its effects through the modulation of some key regulators in ja signaling. we have employed bestatin as an experimental tool to dissect ja signaling through a chemical genetic screening, which yielded a collection of arabidopsis bestatin-resistant (ber) mutants that are insensitive to the inhibitory effects of bestatin on root elongation. further characterization efforts demonstrate that some ber mutants are defective in various ja-induced responses, which allowed us to classify the ber mutants into three phenotypic groups: ja-insensitive ber mutants, ja-hypersensitive ber mutants, and mutants insensitive to bestatin but showing normal response to ja. genetic and phenotypic analyses of the ber mutants with altered ja responses indicate that we have identified several novel loci involved in ja signaling.
WOS关键词	WOUND RESPONSE ; METHYL-JASMONATE ; PROTEINASE-INHIBITORS ; REGULATED DEFENSE ; TOMATO LEAVES ; PLANT-LEAVES ; MUTANT CEV1 ; BIOSYNTHESIS ; RESISTANCE ; THALIANA
WOS研究方向	Plant Sciences
WOS类目	Plant Sciences
语种	英语
出版者	AMER SOC PLANT BIOLOGISTS
WOS记录号	WOS:000239636800024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378455
专题	中国科学院大学
通讯作者	Li, Chuanyou
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Plant Gene Res, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Shandong Agr Univ, Hort Coll, Tai An 271018, Peoples R China 5.Shandong Agr Univ, Agron Coll, Key Lab Crop Biol, Tai An 271018, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Wenguang,Zhai, Qingzhe,Sun, Jiaqiang,et al. Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in arabidopsis[J]. Plant physiology,2006,141(4):1400-1413.
APA	Zheng, Wenguang.,Zhai, Qingzhe.,Sun, Jiaqiang.,Li, Chang-Bao.,Zhang, Lei.,...&Li, Chuanyou.(2006).Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in arabidopsis.Plant physiology,141(4),1400-1413.
MLA	Zheng, Wenguang,et al."Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in arabidopsis".Plant physiology 141.4(2006):1400-1413.

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