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	Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria
	Xie, YX; Bezard, E; Zhao, BL
刊名	Journal of biological chemistry
	2005-09-16
卷号	280期号:37页码:32405-32412
ISSN号	0021-9258
DOI	10.1074/jbc.504664200
通讯作者	Zhao, bl()
英文摘要	Although nicotine has been associated with a decreased risk of developing parkinson disease, the underlying mechanisms are still unclear. by using isolated brain mitochondria, we found that nicotine inhibited n-methyl-4-phenylpyridine (mpp+) and calcium-induced mitochondria high amplitude swelling and cytochrome c release from intact mitochondria. intra-mitochondria redox state was also maintained by nicotine, which could be attributed to an attenuation of mitochondria permeability transition. further investigation revealed that nicotine did not prevent mpp+- or calcium-induced mitochondria membrane potential loss, but instead decreased the electron leak at the site of respiratory chain complex i. in the presence of mecamylamine hydrochloride, a nonselective nicotinic acetylcholine receptor inhibitor, nicotine significantly postponed mitochondria swelling and cytochrome c release induced by a mixture of neurotoxins (mpp+ and 6- hydroxydopamine) in sh-sy5y cells, suggesting that there is a receptor-independent nicotine-mediated neuroprotective effect of nicotine. these results show that interaction of nicotine with mitochondria respiratory chain together with its antioxidant effects should be considered in the neuroprotective effects of nicotine.
WOS关键词	PERMEABILITY TRANSITION PORE ; RESPIRATORY-CHAIN COMPLEX ; ELECTRON-TRANSPORT CHAIN ; CYTOCHROME-C RELEASE ; PARKINSONS-DISEASE ; PYRIDINE-NUCLEOTIDES ; OXIDATIVE STRESS ; CELL-DEATH ; RAT-BRAIN ; IN-VITRO
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
WOS记录号	WOS:000231794800046
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378271
专题	中国科学院大学
通讯作者	Zhao, BL
作者单位	1.Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Bordeaux 2, CNRS, UMR5543, F-33076 Bordeaux, France 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xie, YX,Bezard, E,Zhao, BL. Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria[J]. Journal of biological chemistry,2005,280(37):32405-32412.
APA	Xie, YX,Bezard, E,&Zhao, BL.(2005).Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria.Journal of biological chemistry,280(37),32405-32412.
MLA	Xie, YX,et al."Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria".Journal of biological chemistry 280.37(2005):32405-32412.

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