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	Ph-compensation effect of bioactive inorganic fillers on the degradation of plga
	Li, HY; Chang, J
刊名	Composites science and technology
	2005-11-01
卷号	65期号:14页码:2226-2232
关键词	Plga Ph compensation Bioactive inorganic fillers Scaffolds Degradation
ISSN号	0266-3538
DOI	10.1016/j.compscitech.2005.04.051
通讯作者	Chang, j()
英文摘要	It has been suggested that acidic degradation product of the poly (alpha-hydroxy acids) results in ph decrease in the vicinity of the scaffolds, which may be responsible for biocompatibility concerns rose recently about polylactide acid (pla), polyglycolic acid (pga) polymers and their copolymer poly (lactic acid-co glycolic acid) (plga). this in vitro study was performed to evaluate the ph-compensation ability of bioactive inorganic fillers (bifs) such as wollastonite (w), bioglass 45s5 (bg 45s5) and hydroxyapatite (ha) on the acidic degradation products of plga. three composite scaffolds of plga incorporated with bifs were fabricated and immersed in phosphate buffered saline (pbs, ph 7.4) solution at 37 degrees c for 8 weeks to evaluate the ph changes of the pbs, the mass loss and water absorption of the scaffolds, and the molecular weight loss of the plga in the scaffolds. the results indicated that the ph of the plga group fell to a value of 4.3 in 8 weeks while the ph of the composite groups containing w and bg 45s5 was maintained between 7.7-7.3 and 8.15-7.1 throughout the soaking period, respectively. however, the ph of the composite group containing ha exhibited an almost linear decrease from 7.4 to 5.6 at an average rate of 0.05 per day. in addition, the incorporation of w and bg delayed the degradation of the plga in the composites while the incorporation of ha accelerated the degradation. furthermore, the w and bg in the composite scaffolds accelerated weight loss of the scaffolds and increased their capacity to absorb water during the initial incubation period. all of these results suggested that incorporations of both w and bg 45s5 into plga strongly affected the degradation behavior of scaffolds and were effective in compensation of the ph decrease caused by the acidic degradation products of the plga. (c) 2005 elsevier ltd. all rights reserved.
WOS关键词	TISSUE ENGINEERING APPLICATIONS ; IN-VITRO ; POLY(L-LACTIC ACID) ; COMPOSITES ; SCAFFOLDS ; FOAMS ; FABRICATION ; GLASS ; VIVO ; HYDROXYAPATITE
WOS研究方向	Materials Science
WOS类目	Materials Science, Composites
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000232454400016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378116
专题	中国科学院大学
通讯作者	Chang, J
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Li, HY,Chang, J. Ph-compensation effect of bioactive inorganic fillers on the degradation of plga[J]. Composites science and technology,2005,65(14):2226-2232.
APA	Li, HY,&Chang, J.(2005).Ph-compensation effect of bioactive inorganic fillers on the degradation of plga.Composites science and technology,65(14),2226-2232.
MLA	Li, HY,et al."Ph-compensation effect of bioactive inorganic fillers on the degradation of plga".Composites science and technology 65.14(2005):2226-2232.

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