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	Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells
	Zhang, Y; Cao, EH; Qin, JF
刊名	European journal of pharmacology
	2005-05-23
卷号	516期号:1页码:1-9
关键词	Apoptosis Trf1 Trf2 Reactive oxygen species Arsenic trioxide Telomeric state
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2005.04.022
通讯作者	Cao, eh(caoeh@sun5.ibp.ac.cn)
英文摘要	In this work, our study focused on as(2)o(3) action in view point of telomere. results showed that treatment of human gastric cancer mgc803 cells with arsenic trioxide could cause up-regulation of telomeric repeat binding factor trf1 and trf2 mrna and protein levels, and induced g2/m phase arrest and cell apoptosis. at the same time, telomere length shortening and telomerase inhibitory were not obvious. flow cytometry measurements indicated that the increase of trf1 and trf2 proteins is related to oxidative stress by arsenic trioxide. results also indicate that after arsenic trioxide treatment, p53 protein levels increased significantly and also could bind directly at the telomere t-loop junction. these findings demonstrate arsenic trioxide-induced cell cycle arrest and apoptosis might involve a novel pathway related to trf1, trf2 protein. (c) 2005 elsevier b.v. all rights reserved.
WOS关键词	ARSENIC TRIOXIDE ; IN-VITRO ; INDUCED APOPTOSIS ; DNA ; PROTEIN ; LENGTH ; CYCLE ; LOOP ; P53 ; FIBROBLASTS
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000229849800001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377981
专题	中国科学院大学
通讯作者	Cao, EH
作者单位	Chinese Acad Sci, Grad Sch, Acad Sinica, Inst Biophys, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Y,Cao, EH,Qin, JF. Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells[J]. European journal of pharmacology,2005,516(1):1-9.
APA	Zhang, Y,Cao, EH,&Qin, JF.(2005).Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells.European journal of pharmacology,516(1),1-9.
MLA	Zhang, Y,et al."Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells".European journal of pharmacology 516.1(2005):1-9.

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