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	Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization
	Xie, ZG; Guan, HL; Chen, L; Tian, HY; Chen, XS; Jing, XB
刊名	Polymer
	2005-11-14
卷号	46期号:23页码:10523-10530
关键词	2-methyl-2-carboxyl-propylene carbonate Block copolymer Micellization
ISSN号	0032-3861
DOI	10.1016/j.polymer.2005.08.025
通讯作者	Jing, xb()
英文摘要	A novel amphiphilic biodegradable poly(ethylene glycol)-poly(2-methyl-2-carboxyl-propylene carbonate) (mpeg-pmbc) block copolymer was successfully synthesized by ring-opening polymerization (rop) of 2-methyl-2-carboxyl-propylene carbonate (mbc) with mpeg as a macroinitiator. c-13 nmr and gpc confirmed its structure. it could self-assemble into micelles in aqueous solution with the critical micelle concentration (cmc) as low as similar to 10(-3) g/l. the cmc decreased with increasing pmbc content. dls analyses of the mpeg-pmbc micelles revealed their size of less than 100 nm and narrow size distribution. the micelle size depends much on the copolymer composition and micelle preparation conditions. the morphology of micelle observed by esem is spherical. the obtained polymeric micelles are expected to be used as biomedical materials such as drug delivery vehicles. (c) 2005 elsevier ltd. all rights reserved.
WOS关键词	TRANSFER RADICAL POLYMERIZATION ; AMPHIPHILIC BLOCK-COPOLYMERS ; DRUG-DELIVERY SYSTEMS ; EPSILON-CAPROLACTONE ; OXIDE) BLOCK ; POLY(1,3-TRIMETHYLENE CARBONATE) ; POLY(GAMMA-BENZYL L-GLUTAMATE) ; TRIMETHYLENE CARBONATE ; TRIBLOCK COPOLYMER ; DIBLOCK COPOLYMER
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000232893700109
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377896
专题	中国科学院大学
通讯作者	Jing, XB
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Xie, ZG,Guan, HL,Chen, L,et al. Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization[J]. Polymer,2005,46(23):10523-10530.
APA	Xie, ZG,Guan, HL,Chen, L,Tian, HY,Chen, XS,&Jing, XB.(2005).Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization.Polymer,46(23),10523-10530.
MLA	Xie, ZG,et al."Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization".Polymer 46.23(2005):10523-10530.

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