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	Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola
	Chen, Y; Zhang, YX; Li, MH; Zhao, WM; Shi, YH; Miao, ZH; Zhang, XW; Lin, LP; Ding, J
刊名	Biochemical and biophysical research communications
	2005-04-22
卷号	329期号:4页码:1334-1342
关键词	11,11'-dideoxyverticillin Huvec Angiogenesis Vegf Anticancer
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2005.02.115
通讯作者	Ding, j()
英文摘要	The fungus shiraia bambusicola yields the phytochemical 11,11'-dideoxyverticillin, which has been shown to possess potent anti-cancer activity both in vitro and in vivo. in this study, we reveal that 11,11'-dideoxyverticillin has anti-angiogenic activities and explore the potential mechanisms for this effect. treatment with 11,11'-dideoxyverticillin inhibited the proliferation of human umbilical vein endothelial cells (huvecs) with ic50 values of 0.17 +/- 0.05 mu m for vegf-stimulated cells and 0.39 +/- 0.08 mu m for serum-stimulated cells. 11,11'-dideoxyverticillin also antagonized the antiapoptotic effects of vegf on serum-deprived huvecs, inhibited vegf-induced huvec migration in vitro, and blocked serum-induced huvec tube formation. moreover, 11,11'-dideoxyverticillin completely blocked vegf-induced microvessel sprouting from matrigel-embedded rat aortic rings and vessel growth in matrigel plugs in mice. in addition, 11,11'-dideoxyverticillin decreased vegf secretion by mda-mb-468 breast cancer cells, and significantly suppressed vegf-induced tyrosine phosphorylation of flt-1 and kdr/flk-1. this inhibition of receptor phosphorylation was correlated with a marked decrease in vegf-triggered perk activation and a dramatic increase in pp38 mapk, but no apparent change in pakt. together, these findings strongly suggest that 11,11'-dideoxyverticillin is a structurally novel angiogenesis inhibitor. (c) 2005 elsevier inc. all rights reserved.
WOS关键词	ENDOTHELIAL GROWTH-FACTOR ; IN-VITRO ANGIOGENESIS ; SIGNAL-TRANSDUCTION ; PROTEIN-KINASE ; TUBE FORMATION ; CELL SURVIVAL ; INHIBITION ; RECEPTORS ; PROLIFERATION ; ACTIVATION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000227886300024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377738
专题	中国科学院大学
通讯作者	Ding, J
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Div Antitumor Pharamcol,Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, Y,Zhang, YX,Li, MH,et al. Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola[J]. Biochemical and biophysical research communications,2005,329(4):1334-1342.
APA	Chen, Y.,Zhang, YX.,Li, MH.,Zhao, WM.,Shi, YH.,...&Ding, J.(2005).Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola.Biochemical and biophysical research communications,329(4),1334-1342.
MLA	Chen, Y,et al."Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola".Biochemical and biophysical research communications 329.4(2005):1334-1342.

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