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	A semiparametric regression cure model with current status data
	Lam, KF; Xue, HQ
刊名	Biometrika
	2005-09-01
卷号	92期号:3页码:573-586
关键词	Asymptotically efficient estimator Cured proportion Mixture model Partly linear model Sieve maximum likelihood estimator
ISSN号	0006-3444
DOI	10.1093/biomet/92.3.573
通讯作者	Lam, kf(hrntlkf@hku.hk)
英文摘要	This paper considers the analysis of current status data with a cured proportion in the population using a mixture model that combines a logistic regression formulation for the probability of cure with a semiparametric regression model for the time to occurrence of the event. the semiparametric regression model belongs to the flexible class of partly linear models that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. a sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. under some mild conditions, the estimators are shown to be strongly consistent. the convergence rate of the estimator for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. simulation studies were carried out to investigate the performance of the proposed method and the model is fitted to a dataset from a study of calcification of the hydrogel intraocular lenses, a complication of cataract treatment.
WOS关键词	ADDITIVE HAZARDS REGRESSION ; MIXTURE MODEL ; EFFICIENT ESTIMATION ; LINEAR-REGRESSION
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
WOS类目	Biology ; Mathematical & Computational Biology ; Statistics & Probability
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000231524600006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377450
专题	中国科学院大学
通讯作者	Lam, KF
作者单位	1.Univ Hong Kong, Dept Stat & Actuarial Sci, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Dept Math, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lam, KF,Xue, HQ. A semiparametric regression cure model with current status data[J]. Biometrika,2005,92(3):573-586.
APA	Lam, KF,&Xue, HQ.(2005).A semiparametric regression cure model with current status data.Biometrika,92(3),573-586.
MLA	Lam, KF,et al."A semiparametric regression cure model with current status data".Biometrika 92.3(2005):573-586.

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