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	Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives
	Xia, GX; Li, JF; Peng, AM; Lai, SN; Zhang, SJ; Shen, JS; Liu, ZH; Chen, XJ; Ji, RY
刊名	Bioorganic & medicinal chemistry letters
	2005-06-02
卷号	15期号:11页码:2790-2794
关键词	Pyrido[1,2-e]purin-4(3h)-one Pde5 inhibitor Sildenafil Erectile dysfunction
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2005.03.102
通讯作者	Shen, js()
英文摘要	Synthesis and primary sar of a novel series of 2-phenylpyrido[1,2-e]purin-4(3h)-one derivatives with piperazinyl sulfonamide substituents were described herein. as potential pde5 inhibitors for erectile dysfunction (ed) treatment, representative compounds exhibit improved selectivity versus pde1 and pde6. meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro. (c) 2005 elsevier ltd. all rights reserved.
WOS关键词	MALE ERECTILE DYSFUNCTION ; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES ; SELECTIVE PDE5 INHIBITORS ; POTENT ; SILDENAFIL ; CAVERNOSUM ; ANALOGS ; RELAXATION ; EXPRESSION ; ISOFORMS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS类目	Chemistry, Medicinal ; Chemistry, Organic
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000229665600019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377415
专题	中国科学院大学
通讯作者	Shen, JS
作者单位	1.Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xia, GX,Li, JF,Peng, AM,et al. Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives[J]. Bioorganic & medicinal chemistry letters,2005,15(11):2790-2794.
APA	Xia, GX.,Li, JF.,Peng, AM.,Lai, SN.,Zhang, SJ.,...&Ji, RY.(2005).Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives.Bioorganic & medicinal chemistry letters,15(11),2790-2794.
MLA	Xia, GX,et al."Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives".Bioorganic & medicinal chemistry letters 15.11(2005):2790-2794.

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