QQ客服 官方微博 反馈留言

	An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer
	Gao Yu-Zhe1,4; Zhang Lei1,4; Huo Wei-Song1,4; Shi Stone2; Lian Jie3; Gao Yun-Hua1
刊名	Chinese journal of analytical chemistry
	2015-06-01
卷号	43期号:6页码:802-807
关键词	Giant magnetoresistance Microfluidic immuno-sensor D-dimer Magnetic particles
ISSN号	0253-3820
DOI	10.1016/s1872-2040(15)60827-1
通讯作者	Gao yun-hua(yhgao@mail.ipc.ac.cn)
英文摘要	A method for rapid detection and quantification of d-dimer as a biomarker of thrombosis was developed by utilizing giant magnetoresistance (gmr) sensor integrated with microfluidic technique and 100 nm magnetic particles (mps) as signal probes. the mps binding on the chip through specific immune reaction were measured by the gmr sensor and the concentration of d-dimer was obtained at the same time. the detection range of this method was from 5 ng ml(-1) to 6500 ng ml(-1), the detection limit was 5 ng ml(-1), the intra relative standard deviation was less than 12% and the inter relative standard deviation was less than 14%. the whole analysis process could be completed within 9 min, and a good linear correlation between the results of gmr biosensor and sysmex ca1500 was obtained. the method had the advantages such as high sensitivity, fast detection and good accuracy.
WOS关键词	DEEP-VEIN THROMBOSIS ; MAGNETIC NANOPARTICLES ; VENOUS THROMBOEMBOLISM ; PULMONARY-EMBOLISM ; EXCLUSION ; DIAGNOSIS ; ASSAY
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000356301700001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376749
专题	中国科学院大学
通讯作者	Gao Yun-Hua
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Dongguan Bosh Biotechnol LTD, Dongguan 523808, Peoples R China 3.Peoples Publ Secur Univ China, Dept Forens Sci, Beijing 10038, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gao Yu-Zhe,Zhang Lei,Huo Wei-Song,et al. An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer[J]. Chinese journal of analytical chemistry,2015,43(6):802-807.
APA	Gao Yu-Zhe,Zhang Lei,Huo Wei-Song,Shi Stone,Lian Jie,&Gao Yun-Hua.(2015).An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer.Chinese journal of analytical chemistry,43(6),802-807.
MLA	Gao Yu-Zhe,et al."An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer".Chinese journal of analytical chemistry 43.6(2015):802-807.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。