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	Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression
	Xu, Yi1; Chang, Renxu1; Peng, Zhiyong2,3; Wang, Yanmei1; Ji, Weiwei1; Guo, Jingyu1; Song, Lele1; Dai, Cheng1; Wei, Wei1; Wu, Yanjun1
刊名	Nature communications
	2015-05-01
卷号	6页码:12
ISSN号	2041-1723
DOI	10.1038/ncomms8184
通讯作者	Zhan, lixing(lxzhan@sibs.ac.cn)
英文摘要	Pancreatic cancer (pc) is a particularly lethal form of cancer with high potential for metastasis to distant organs. disruption of cell polarity is a hallmark of advanced epithelial tumours. here we show that the polarity protein af6 (afadin and mllt4) is expressed at low levels in pc. we demonstrate that depletion of af6 markedly promotes proliferation and metastasis of pc cells through upregulation of the expression of snail protein, and this requires the nuclear localization of af6. furthermore, af6 deficiency in pc cells leads to increased formation of a dishevelled 2 (dvl2)-foxe1 complex on the promoter region of snail gene, and activation of snail expression. altogether, our data established af6 as a potential inhibitor of metastasis in pc cells. targeting the dvl2-foxe1-snail signalling axis may thus represent a promising therapeutic strategy.
WOS关键词	CELL-CELL JUNCTIONS ; BREAST-CANCER ; ADHERENS JUNCTION ; BETA-CATENIN ; PDZ DOMAIN ; RAS ; AFADIN ; GENE ; MIGRATION ; MLL-AF6
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000355536900003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376675
专题	中国科学院大学
通讯作者	Zhan, Lixing
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghaim 200031, Peoples R China 2.Second Mil Med Univ, Changhai Hosp, Dept Pancreat Surg, Shanghai 200433, Peoples R China 3.Second Mil Med Univ, Navy Med Res Inst, Shanghai 200433, Peoples R China 4.Tongji Univ, Sch Med, Shanghai Peoples Hosp 2, Dept Gastroenterol, Shanghai 200011, Peoples R China 5.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yi,Chang, Renxu,Peng, Zhiyong,et al. Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression[J]. Nature communications,2015,6:12.
APA	Xu, Yi.,Chang, Renxu.,Peng, Zhiyong.,Wang, Yanmei.,Ji, Weiwei.,...&Zhan, Lixing.(2015).Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression.Nature communications,6,12.
MLA	Xu, Yi,et al."Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression".Nature communications 6(2015):12.

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