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	Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats
	Xing, Ronge1; He, Xiaofei1,2; Liu, Song1; Yu, Huahua1; Qin, Yukun1; Chen, Xiaolin1; Li, Kecheng1; Li, Rongfeng1; Li, Pengcheng1
刊名	Marine drugs
	2015-05-01
卷号	13期号:5页码:3072-3090
关键词	Differently regioselective chitosan sulfates Hypoglycemic activity Glucose tolerance Plasma insulin Alloxan-induced diabetic rats
ISSN号	1660-3397
DOI	10.3390/md13053072
通讯作者	Xing, ronge(xingronge@qdio.ac.cn)
英文摘要	The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. the differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-o-sulfochitosan (3-s). the major results are as follows. first, 3,6-di-o-sulfochitosan and 3-o-sulfochitosan exhibited more significant hypoglycemic activities than 2-n-3, 6-di-o-sulfochitosan and 6-o-sulfochitosan. moreover, 3-s-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-o-sulfochitosan. these results indicated that -oso3- at the c3-position of chitosan is a key active site. second, 3-s significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. third, treatment with 3-s significantly increased the plasma insulin levels in the experimental diabetic rats. a noticeable hypoglycemic activity of 3-s in the alloxan-induced diabetic rats was shown. clinical trials are required in the future to confirm the utility of 3-s.
WOS关键词	OXIDATIVE STRESS ; MECHANISM ; TISSUES ; FRUIT
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000356241100026
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376475
专题	中国科学院大学
通讯作者	Xing, Ronge
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xing, Ronge,He, Xiaofei,Liu, Song,et al. Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats[J]. Marine drugs,2015,13(5):3072-3090.
APA	Xing, Ronge.,He, Xiaofei.,Liu, Song.,Yu, Huahua.,Qin, Yukun.,...&Li, Pengcheng.(2015).Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats.Marine drugs,13(5),3072-3090.
MLA	Xing, Ronge,et al."Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats".Marine drugs 13.5(2015):3072-3090.

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