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	Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach
	Yao, Xuan1,2,3; Sa, Rina1,2; Ye, Cheng1,2; Zhang, Duo1,2; Zhang, Shengjie1,2; Xia, Hongfeng1,2; Wang, Yu-Cheng3,4; Jiang, Jingjing5; Yin, Huiyong1,2; Ying, Hao1,2,3
刊名	Prostaglandins & other lipid mediators
	2015-04-01
卷号	118页码:11-18
关键词	Arachidonic acid metabolites Targeted metabolomic approach Hypothyroidism Hyperthyroidism Cardiovascular disorders
ISSN号	1098-8823
DOI	10.1016/j.prostaglandins.2015.03.005
通讯作者	Ying, hao(yinghao@sibs.ac.cn)
英文摘要	Symptoms of cardiovascular diseases are frequently found in patients with hypothyroidism and hyperthyroidism. however, it is unknown whether arachidonic acid metabolites, the potent mediators in cardiovascular system, are involved in cardiovascular disorders caused by hyperthyroidism and hypothyroidism. to answer this question, serum levels of arachidonic acid metabolites in human subjects with hypothyroidism, hyperthyroidism and mice with hypothyroidism or thyroid hormone treatment were determined by a mass spectrometry-based method. over ten arachidonic acid metabolites belonging to three catalytic pathways: cyclooxygenases, lipoxygenases, and cytochrome p450, were quantified simultaneously and displayed characteristic profiles under different thyroid hormone status. the level of 20-hydroxyeicosatetraenoic acid, a cytochrome p450 metabolite, was positively correlated with thyroid hormone level and possibly contributed to the elevated blood pressured in hyperthyroidism. the increased prostanoid (pg) 12 and decreased pge(2) levels in hypothyroid patients might serve to alleviate atherosclerosis associated with dyslipidemia. the elevated level of thromboxane (tx) a(2), as indicated by txb2, in hyperthyroid patients and mice treated with thyroid hormone might bring about pulmonary hypertension frequently found in hyperthyroid patients. in conclusion, our prospective study revealed that arachidonic acid metabolites were differentially affected by thyroid hormone status. certain metabolites may be involved in cardiovascular disorders associated with thyroid diseases. (c) 2015 elsevier inc. all rights reserved.
WOS关键词	PULMONARY-HYPERTENSION ; CARDIOVASCULAR-SYSTEM ; WHICKHAM SURVEY ; NT-PROBNP ; DISEASE ; ATHEROSCLEROSIS ; HYPERTHYROIDISM ; PROSTACYCLIN ; COMMUNITY ; HEALTH
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000356637500002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376441
专题	中国科学院大学
通讯作者	Ying, Hao
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Clin Res Ctr, Shanghai 200031, Peoples R China 4.Shanghai Xuhui Cent Hosp, Dept Nutr, Shanghai 200031, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Yao, Xuan,Sa, Rina,Ye, Cheng,et al. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach[J]. Prostaglandins & other lipid mediators,2015,118:11-18.
APA	Yao, Xuan.,Sa, Rina.,Ye, Cheng.,Zhang, Duo.,Zhang, Shengjie.,...&Ying, Hao.(2015).Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach.Prostaglandins & other lipid mediators,118,11-18.
MLA	Yao, Xuan,et al."Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach".Prostaglandins & other lipid mediators 118(2015):11-18.

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