QQ客服 官方微博 反馈留言

	Tailor-made stable zr(iv)-based metal-organic frameworks for laser desorption/ionization mass spectrometry analysis of small molecules and simultaneous enrichment of phosphopeptides
	Chen, Lianfang1,2; Ou, Junjie1; Wang, Hongwei1; Liu, Zhongshan1,2; Ye, Mingliang1; Zou, Hanfa
刊名	Acs applied materials & interfaces
	2016-08-10
卷号	8期号:31页码:20293-20301
关键词	Metal-organic frameworks Uio-66-pdc Uio-66-(oh)(2) Ldi-ms Small molecules
ISSN号	1944-8244
DOI	10.1021/acsami.6b06225
通讯作者	Ou, junjie(junjieou@dicp.ac.cn) ; Ye, mingliang(mingliang@dicp.ac.cn)
英文摘要	Although thousands of metal organic frameworks (mofs) have been fabricated and widely applied in gas storage/separations, adsorption, catalysis, and so on, few kinds of mofs have been used as adsorption materials while simultaneously serving as matrixes to analyze small molecules for laser desorption/ionization mass spectrometry (ldi-ms). herein, a new concept is introduced to design and synthesize mofs as both adsorption materials and matrixes according to the structure of ligands and common matrixes. the proof of concept design was demonstrated by selection of 2,5-pyridinedicarboxylic acid (pdc) and 2,5-dihydroxyterephthalic acid (dht) as ligands for synthesis of mofs. two zr(iv)based mofs of uio-66-pdc and uio-66-(oh)(2) were synthesized and applied for the first time as new matrixes for analysis of small molecules by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof-ms). both of them showed low matrix interferences, high ionization efficiency, and good reproducibility when used as matrixes. a variety of small molecules, including saccharides, amino acids, nucleosides, peptides, alkaline drugs, and natural products, were analyzed. in addition, uio-66-(oh)(2) exhibited potential for application in the quantitative determination of glucose and pyridoxal 5'-phosphate. furthermore, thanks to its intrinsically large surface area and highly ordered pores, ui0-66-(oh)(2) also showed sensitive and specific enrichment of phosphopeptides prior to ms analysis. these results demonstrated that this strategy can be used to efficiently screen tailor-made mofs as matrixes to analyze small molecules by maldi-tof-ms.
WOS关键词	CHEMISTRY ; SEPARATION ; STABILITY ; DESIGN ; MATRIX ; SENSORS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000381331600053
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376194
专题	中国科学院大学
通讯作者	Ou, Junjie; Ye, Mingliang
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Lianfang,Ou, Junjie,Wang, Hongwei,et al. Tailor-made stable zr(iv)-based metal-organic frameworks for laser desorption/ionization mass spectrometry analysis of small molecules and simultaneous enrichment of phosphopeptides[J]. Acs applied materials & interfaces,2016,8(31):20293-20301.
APA	Chen, Lianfang,Ou, Junjie,Wang, Hongwei,Liu, Zhongshan,Ye, Mingliang,&Zou, Hanfa.(2016).Tailor-made stable zr(iv)-based metal-organic frameworks for laser desorption/ionization mass spectrometry analysis of small molecules and simultaneous enrichment of phosphopeptides.Acs applied materials & interfaces,8(31),20293-20301.
MLA	Chen, Lianfang,et al."Tailor-made stable zr(iv)-based metal-organic frameworks for laser desorption/ionization mass spectrometry analysis of small molecules and simultaneous enrichment of phosphopeptides".Acs applied materials & interfaces 8.31(2016):20293-20301.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。