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	Insight into several factors that affect the conversion between antioxidant and oxidant activities of nanoceria
	Lu, Mei; Zhang, Yan; Wang, Yiwen; Jiang, Miao; Yao, Xin
刊名	Acs applied materials & interfaces
	2016-09-14
卷号	8期号:36页码:23580-23590
关键词	Nanoceria Antioxidant activity Oxidant activity Conversion factors Hydroxyl radicals
ISSN号	1944-8244
DOI	10.1021/acsami.6b08219
通讯作者	Yao, xin(yaox@ucas.ac.cn)
英文摘要	Many conflicting results have been reported related to the antioxidant and oxidant activities of nanoceria. on the basis of this research, many factors might affect the antioxidant activity of nanoceria. however, all of the factors reported only affect the antioxidant activity of nanoceria to a limited extent or cause the antioxidant activity to be lost. we found that several factors can induce conversion between the protective effect and toxicity of nanoceria. at low concentrations of hydroxyl radicals (center dot oh) and nanomaterials, nanoceria exhibited antioxidant activity but could produce greater amounts of center dot oh at higher center dot oh or nanomaterial concentrations and subsequently exhibit oxidant activity. moreover, the morphology and size of nanoceria can also affect:this conversion. we found that high concentrations of center dot oh and nanoceria could introduce a high amount of ce3+ in the system, which might be the reason that nanoceria converted from exhibiting antioxidant to oxidant activity. under this condition, nanoceria act as catalyst similar to fe2+ to promote center dot oh production in a fenton system and also as a catalyst promoter to boost fe2+ production of additional center dot oh during the redox reaction. these conclusions support a better understanding of conflicting reports on medicinal applications for nanoceria and promote their practical application.
WOS关键词	HUMAN DERMAL FIBROBLASTS ; CERIUM OXIDE ; CEO2 NANOPARTICLES ; OXIDATIVE STRESS ; IN-VITRO ; COATED NANOCERIA ; CEO2/H2O2 SYSTEM ; MIMETIC ACTIVITY ; TOXICITY ; CELLS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000383412000017
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376013
专题	中国科学院大学
通讯作者	Yao, Xin
作者单位	Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lu, Mei,Zhang, Yan,Wang, Yiwen,et al. Insight into several factors that affect the conversion between antioxidant and oxidant activities of nanoceria[J]. Acs applied materials & interfaces,2016,8(36):23580-23590.
APA	Lu, Mei,Zhang, Yan,Wang, Yiwen,Jiang, Miao,&Yao, Xin.(2016).Insight into several factors that affect the conversion between antioxidant and oxidant activities of nanoceria.Acs applied materials & interfaces,8(36),23580-23590.
MLA	Lu, Mei,et al."Insight into several factors that affect the conversion between antioxidant and oxidant activities of nanoceria".Acs applied materials & interfaces 8.36(2016):23580-23590.

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