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	Effects of dietary protein restriction on muscle fiber characteristics and mtorc1 pathway in the skeletal muscle of growing-finishing pigs
	Li, Yinghui1,2,3,4; Li, Fengna1,2,3,5,6; Wu, Li1,2,3; Wei, Hongkui7; Liu, Yingying1,2,3; Li, Tiejun1,2,3; Tan, Bie1,2,3,5,6; Kong, Xiangfeng1,2,3; Yao, Kang1,2,3,5,6; Chen, Shuai1,2,3
刊名	Journal of animal science and biotechnology
	2016-08-22
卷号	7页码:12
关键词	Dietary protein restriction Energy status Growing-finishing pigs Mtorc1 Muscle fiber type
ISSN号	2049-1891
DOI	10.1186/s40104-016-0106-8
通讯作者	Li, fengna(lifengna@isa.ac.cn) ; Yin, yulong(yinyulong@isa.ac.cn)
英文摘要	Background: to investigate the effects of dietary crude protein (cp) restriction on muscle fiber characteristics and key regulators related to protein deposition in skeletal muscle, a total of 18 growing-finishing pigs (62.30 +/- 0.88 kg) were allotted to 3 groups and fed with the recommended adequate protein (ap, 16 % cp) diet, moderately restricted protein (mp, 13 % cp) diet and low protein (lp, 10 % cp) diet, respectively. the skeletal muscle of different locations in pigs, including longissimus dorsi muscle (ldm), psoas major muscle (pmm) and biceps femoris muscle (bfm) were collected and analyzed. results: results showed that growing-finishing pigs fed the mp or ap diet improved (p < 0.01) the average daily gain and feed: gain ratio compared with those fed the lp diet, and the mp diet tended to increase (p = 0.09) the weight of ldm. moreover, the atp content and energy charge value were varied among muscle samples from different locations of pigs fed the reduced protein diets. we also observed that pigs fed the mp diet up-regulated (p < 0.05) muscular mrna expression of all the selected key genes, except that myosin heavy chain (myhc) iib, myhc iix, while mrna expression of ubiquitin ligases genes was not affected by dietary cp level. additionally, the activation of mammalian target of rapamycin complex 1 (mtorc1) pathway was stimulated (p < 0.05) in skeletal muscle of the pigs fed the mp or ap diet compared with those fed the lp diet. conclusion: the results suggest that the pigs fed the mp diet could catch up to the growth performance and the ldm weight of the pigs fed the ap diet, and the underlying mechanism may be partly due to the alteration in energy status, modulation of muscle fiber characteristics and mtorc1 activation as well as its downstream effectors in skeletal muscle of different locations in growing-finishing pigs.
WOS关键词	POSTMORTEM METABOLIC-RATE ; AMINO-ACIDS ; CARCASS CHARACTERISTICS ; TRANSLATION INITIATION ; MEAT QUALITY ; BIOCHEMICAL-PROPERTIES ; RESISTANCE EXERCISE ; NEONATAL PIGS ; ELDERLY-WOMEN ; RNA-CONTENT
WOS研究方向	Agriculture
WOS类目	Agriculture, Dairy & Animal Science
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000383542400001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376007
专题	中国科学院大学
通讯作者	Li, Fengna; Yin, Yulong
作者单位	1.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, 644 Yuanda Rd, Changsha 410125, Hunan, Peoples R China 2.Engn Res Ctr Hlth Livestock & Poultry Prod, 644 Yuanda Rd, Changsha 410125, Hunan, Peoples R China 3.Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, 644 Yuanda Rd, Changsha 410125, Hunan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 5.CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China 6.Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China 7.Huazhong Agr Univ, Coll Anim Sci, Wuhan 430070, Hubei, Peoples R China 8.Hunan Normal Univ, Sch Biol, Changsha 410018, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Li, Yinghui,Li, Fengna,Wu, Li,et al. Effects of dietary protein restriction on muscle fiber characteristics and mtorc1 pathway in the skeletal muscle of growing-finishing pigs[J]. Journal of animal science and biotechnology,2016,7:12.
APA	Li, Yinghui.,Li, Fengna.,Wu, Li.,Wei, Hongkui.,Liu, Yingying.,...&Yin, Yulong.(2016).Effects of dietary protein restriction on muscle fiber characteristics and mtorc1 pathway in the skeletal muscle of growing-finishing pigs.Journal of animal science and biotechnology,7,12.
MLA	Li, Yinghui,et al."Effects of dietary protein restriction on muscle fiber characteristics and mtorc1 pathway in the skeletal muscle of growing-finishing pigs".Journal of animal science and biotechnology 7(2016):12.

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